Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Influence of central nicotinic receptors on arachidonylcyclopropylamide (ACPA)-induced antinociception in mice

(2008) Influence of central nicotinic receptors on arachidonylcyclopropylamide (ACPA)-induced antinociception in mice. INTERNATIONAL JOURNAL OF NEUROSCIENCE. pp. 531-543.

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Abstract

The nicotinic cholinergic receptors have been reported to be involved in several actions of cannabinoids (e.g., bradycardia, hypothermia). However, the influence of central cholinergic system on cannabinoids antinociceptive effect has not been reported. This study investigated the possible part played by nicotinic cholinergic modulator drugs on the antinociceptive effect of central administration of arachidonylcyclopropylamide (ACPA) in mice. The antinociceptive effects of intracerebroventricular (i.c.v.) administration of ACPA using the formalin test have been studied in mice. The effects of nicotine or mecamylamine (a nicotinic cholinergic antagonist) on ACPA analgesia are also studied. i.c.v. administration of ACPA (0.004-1 mu g/mice) induced antinociceptive effect in mice. i.c.v. administration of nicotine (0.1 or 0.5 mu g/mice) or mecamylamine (2 mu g/mice) potentiated or antagonized ACPA antinociceptive effects, respectively. It is concluded that ACPA-induced analgesia is influenced by central nicotinic cholinergic activity.

Item Type: Article
Keywords: ACPA; antinociception; formalin test; nicotinic receptors
Page Range: pp. 531-543
Journal or Publication Title: INTERNATIONAL JOURNAL OF NEUROSCIENCE
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 118
Number: 4
Publisher: web of science,pubmed,scopus
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/991

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