Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Nanobodies As Novel Agents for Targeting Angiogenesis in Solid Cancers

(2017) Nanobodies As Novel Agents for Targeting Angiogenesis in Solid Cancers. Frontiers in Immunology. p. 13. ISSN 1664-3224

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Abstract

Solid cancers are dependent on angiogenesis for sustenance. The FDA approval of Bevacizumab in 2004 inspired many scientists to develop more inhibitors of angiogenesis. Although several monoclonal antibodies (mAbs) are being administered to successfully combat various pathologies, the complexity and large size of mAbs seem to narrow the therapeutic applications. To improve the performance of cancer therapeutics, including those blocking tumor angiogenesis, attractive strategies such as miniaturization of the antibodies have been introduced. Nanobodies (Nbs), small single-domain antigen-binding antibody fragments, are becoming promising therapeutic and diagnostic proteins in oncology due to their favorable unique structural and functional properties. This review focuses on the potential and state of the art of Nbs to inhibit the angiogenic process for therapy and the use of labeled Nbs for non-invasive in vivo imaging of the tumors.

Item Type: Article
Keywords: angiogenesis nanobody monoclonal antibody cancer therapy vascular endothelial growth factor family GROWTH-FACTOR RECEPTOR SINGLE-DOMAIN ANTIBODIES ANTI-EGFR NANOBODIES ANTI-HER2 NANOBODY BISPECIFIC ANTIBODIES MONOCLONAL-ANTIBODIES BREAST-CANCER HIGH-AFFINITY IN-VIVO PHASE-I Immunology
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Page Range: p. 13
Journal or Publication Title: Frontiers in Immunology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 8
Identification Number: https://doi.org/10.3389/fimmu.2017.01746 <Go to ISI>://WOS:000417471900001
ISSN: 1664-3224
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/9

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