Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Influence of beta-adrenoceptor agonists and antagonists on baclofen-induced memory impairment in mice

(2004) Influence of beta-adrenoceptor agonists and antagonists on baclofen-induced memory impairment in mice. BEHAVIOURAL PHARMACOLOGY. pp. 293-297.

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Abstract

Post-training administration of different doses of baclofen (a GABA(B) agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta(1)-agonist) or salbutamol (a beta(2)-agonist) reversed the memory impairment induced by baclofen without exhibiting intrinsic actions on memory when administered alone. The administration of atenolol (a beta(1)-antagonist) or propranolol (a beta-antagonist) produced a memory impairment. When co-administered with baclofen, both atenolol and propranolol exacerbated the memory impairment induced by the GABA(B) agonist. It is concluded that beta-adrenergic mechanisms may be involved in the modulation of memory via GABA(B) receptors.

Item Type: Article
Keywords: memory; baclofen; passive avoidance; dobutamine; salbutamol; atenolol; propranolol; mouse
Page Range: pp. 293-297
Journal or Publication Title: BEHAVIOURAL PHARMACOLOGY
Abstract and Indexing: ISI, Scopus
Quartile : Q4
Volume: 15
Number: 4
Publisher: web of science
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/857

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