Abstract

Post-training administration of different doses of baclofen (a GABA(B) agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta(1)-agonist) or salbutamol (a beta(2)-agonist) reversed the memory impairment induced by baclofen without exhibiting intrinsic actions on memory when administered alone. The administration of atenolol (a beta(1)-antagonist) or propranolol (a beta-antagonist) produced a memory impairment. When co-administered with baclofen, both atenolol and propranolol exacerbated the memory impairment induced by the GABA(B) agonist. It is concluded that beta-adrenergic mechanisms may be involved in the modulation of memory via GABA(B) receptors.