Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Diabetes mellitus, obesity, and risk of pancreatic ductal adenocarcinoma: A large case-control study from Iran

(2021) Diabetes mellitus, obesity, and risk of pancreatic ductal adenocarcinoma: A large case-control study from Iran. Middle East Journal of Digestive Diseases. pp. 15-20. ISSN 20085230

[img] Text
2204-7936-1-PB.pdf

Download (331kB)

Official URL: http://mejdd.org/index.php/mejdd/article/view/2204...

Abstract

BACKGROUND Pancreatic cancer (PC) is a deadly, globally increasing cancer. The causes of PC are still insufficiently known, however smoking, diabetes mellitus (DM), and obesity have been identified as risk factors of PC, mostly in the developed countries. We evaluated these risk factors and their contribution to PC among an Iranian population. METHODS Cases and controls were selected from patients who were registered to a tertiary gastrointestinal diseases referral hospital in Tehran, Iran, from Jan 2012 to Jan 2018. Information on risk factors was collected by personal interview using a structured questionnaire. Logistic regression models were used to calculate adjusted odds ratios (AORs) and 95 confidence intervals (CIs). RESULTS We recruited 470 new patients with histopathological PC diagnosis and 526 sex and age-matched controls. Cigarette-smoking AOR: 1.65 (1.15-2.38), opium use AOR: 1.58 (1.06-2.35), DM AOR: 1.99 (1.31-3.02), and having a history of any cancer in a first-degree family member AOR: 1.53 (1.14-2.05) were associated with an increased risk of PC. We did not find an association between obesity AOR: 0.99 (0.71-1.38) and PC. Approximately 4.6%, 5.9%, 8.2%, and 10.9% risk of PC were related to cigarette-smoking, opium use, DM, and family history of any cancer, respectively. CONCLUSION This study supports that DM is associated with PC risk; however, similar to many studies in Asia, obesity is not associated with PC in Iranians. DM has the highest impact on PC development in Iranian women. © 2021 The Author(s).

Item Type: Article
Keywords: Diabetes mellitus; Obesity; Pancreas neoplasms; Risk factor
Subjects: QZ Pathology > QZ 200-380 Neoplasms
WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 100-175 Nutrition Disorders
WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 200-226 Metabolic Diseases
WI Digestive System > WI 800-830 Pancreas
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Internal
Page Range: pp. 15-20
Journal or Publication Title: Middle East Journal of Digestive Diseases
Abstract and Indexing: Pubmed, Scopus
Quartile : Q4
Volume: 13
Number: 1
Publisher: Shriaz University of Medical Sciences
Identification Number: https://doi.org/10.34172/mejdd.2021.198
ISSN: 20085230
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/8009

Actions (login required)

View Item View Item