Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Genetic variants and risk of thyroid cancer among Iranian patients

(2021) Genetic variants and risk of thyroid cancer among Iranian patients. Hormone Molecular Biology and Clinical Investigation. ISSN 18681883

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Official URL: https://www.degruyter.com/document/doi/10.1515/hmb...

Abstract

The definition of an exclusive panel of genetic markers is of high importance to initially detect among this review population. Therefore, we gave a summary of each main genetic marker among Iranian patients with thyroid cancer for the first time which were classified based on their cellular function. Due to the results, a significant relationship was found between SNP in codons 194, 280, and 399 (XRCC1), Allele 3434Thr (XRCC7), GC or CC genotype 31, G/C (Survivin), 399G>A (XRCC1), Tru9I (vitamin D receptor), G-D haplotype (MDM2), TT genotype, -656 G/T (IL-18), TAGTT haplotype (IL-18), G allele in +49 A>G (CTLA-4), +7146 G/A (PD-1.3), +7785 C/T (PD-1.5), rs1143770 (let7a-2), rs4938723 (pri-mir-34b/c) genes, and thyroid cancers. Moreover, SNP in 677C - >T (MTHFR), GG genotype Asp1312Gly (thyroglobulin), 2259C>T (Rad52), R188H, (XRCC2), T241M (XRCC3) had higher risks of thyroid cancer and lower risks were observed in -16 Ins-Pro (p53), rs3742330 (DICER1). At last, the protective effects were explored in 127 CC genotype (IL-18), rs6877842 (DROSHA). Conduct further studies on the types of DNA repair gene polymorphisms with a larger number in the thyroid cancer using modern methods such as SNP array so that these genes could be used as a biomarker in prediction, diagnosis, and treatment of thyroid cancer. This review presents for the first time a summary of important genetic markers in Iranian patients with thyroid cancer. © 2021 Walter de Gruyter GmbH, Berlin/Boston 2021.

Item Type: Article
Keywords: biomarker; genotyping; Iran; single nucleotide polymorphisms; thyroid cancer
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QZ Pathology > QZ 200-380 Neoplasms
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Microbiology
Journal or Publication Title: Hormone Molecular Biology and Clinical Investigation
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Publisher: De Gruyter Open Ltd
Identification Number: https://doi.org/10.1515/hmbci-2020-0051
ISSN: 18681883
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/8008

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