Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

MicroRNAs: roles in cardiovascular development and disease

(2021) MicroRNAs: roles in cardiovascular development and disease. Cardiovascular Pathology. ISSN 10548807

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Official URL: https://www.sciencedirect.com/science/article/abs/...

Abstract

Cardiovascular diseases (CVDs) comprise a group of disorders ranging from peripheral artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to arrhythmias and ultimately, heart failure. For all the advances in therapeutics, CVDs are still the leading cause of mortality the world over, hence the significance of a thorough understanding of CVDs at the molecular level. Disparities in the expressions of genes and microRNAs (miRNAs) play a crucial role in the determination of the fate of cellular pathways, which ultimately affect an organism's physiology. Indeed, miRNAs serve as the regulators of gene expressions in that they perform key functions both in several important cellular pathways and in the regulation of the onset of various diseases such as CVDs. Many miRNAs are expressed in embryonic, postnatal, and adult hearts; their aberrant expression or genetic deletion is associated with abnormal cardiac cell differentiation, disruption in heart development, and cardiac dysfunction. A substantial body of evidence implicates miRNAs in CVD development and suggests them as diagnostic biomarkers and intriguing therapeutic tools. The present review provides an overview of the history, biogenesis, and processing of miRNAs, as well as their function in the development, remodeling, and diseases of the heart. © 2020 Elsevier Inc.

Item Type: Article
Keywords: microRNA; microRNA 1; microRNA 126; microRNA 128a; microRNA 130; microRNA 133; microRNA 138; microRNA 143; microRNA 145; microRNA 15; microRNA 17 92; microRNA 208a; microRNA 218; microRNA 499; microRNA let 7; unclassified drug; microRNA, biogenesis; cardiomyopathy; cardiovascular disease; congenital heart disease; heart development; heart failure; heart muscle fibrosis; heart muscle ischemia; heart ventricle remodeling; human; nonhuman; priority journal; Review; RNA processing; animal; cardiovascular disease; cardiovascular system; gene expression regulation; gene therapy; genetic marker; genetics; growth, development and aging; morphogenesis; pathophysiology, Animals; Cardiovascular Diseases; Cardiovascular System; Gene Expression Regulation, Developmental; Genetic Markers; Genetic Therapy; Humans; MicroRNAs; Morphogenesis
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Cardiovascular System > WG 200-460 Heart. Heart Diseases
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics
Journal or Publication Title: Cardiovascular Pathology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 50
Publisher: Elsevier Inc.
Identification Number: https://doi.org/10.1016/j.carpath.2020.107296
ISSN: 10548807
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/8007

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