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Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Effect of baseline resistance-associated substitutions on thalassemia patients with chronic hcv infection: A two-year follow-up

(2021) Effect of baseline resistance-associated substitutions on thalassemia patients with chronic hcv infection: A two-year follow-up. Middle East Journal of Digestive Diseases. pp. 27-34. ISSN 20085230

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Abstract

BACKGROUND Direct-acting antivirals (DAAs) against hepatitis C virus (HCV) infection showed the presence of resistant-associated substitutions (RASs). The aim of the present study was to carry out a follow-up of patients with baseline RASs to report the impact of RASs on DAA therapy outcome. METHODS In a cohort study, we analyzed NS5A and NS5B RASs among nine thalassemia cases by baseline RASs. In a 2-year follow-up, we analyzed viral markers and biochemical and hematological parameters of the participants and their sustained virologic response (SVR). Statistical analyses were performed using SPSS software version 22. RESULTS RASs for HCV subtype 1a included M28V, L31M, and H58P. For subtype 1b: L28M, R30Q, S24F, and C316N. And for subtype 3a: C316S, and S24F. In patients with cirrhosis (n = 5), ALT (p = 0.001) and AST (p = 0.007) levels were significantly reduced after treatment, and creatinine level slightly increased (p = 0.025). However, no significant data was observed in non-cirrhotic patients following the treatment. CONCLUSION The present study did not show any adverse effects of DAA therapy among patients with thalassemia suffering from chronic HCV infection with baseline RASs. Furthermore, reduction in ferritin and liver stiffness levels after DAA therapy could show the efficacy of DAA in such patients. © 2021 The Author(s).

Item Type: Article
Keywords: Chronic HCV infection; Direct acting antivirals (DAAs); Resistant associated substitutions (RASs)
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
Page Range: pp. 27-34
Journal or Publication Title: Middle East Journal of Digestive Diseases
Abstract and Indexing: Pubmed, Scopus
Quartile : Q4
Volume: 13
Number: 1
Publisher: Shriaz University of Medical Sciences
Identification Number: https://doi.org/10.34172/mejdd.2021.200
ISSN: 20085230
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/8006

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