Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Efficient synthesis of novel 2-(2-chloroquinolin-3-yl)imidazo1,2-apyridin-3-amine derivatives

(2021) Efficient synthesis of novel 2-(2-chloroquinolin-3-yl)imidazo1,2-apyridin-3-amine derivatives. Journal of the Chinese Chemical Society. ISSN 00094536

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Official URL: https://onlinelibrary.wiley.com/doi/epdf/10.1002/j...

Abstract

An efficient method is applied for the synthesis of novel 2-(2-chloroquinolin-3-yl)-N-alkylimidazo1,2-apyridin-3-amine derivatives. The method is based on a two-step approach from acetanilide, 2-chloro-3-formyl quinoline, 2-aminopyridine, and isocyanide under mild reaction conditions. In the first step, acetanilide forms 2-chloroquinoline-3-carbaldehyde in the presence of phosphoryl chloride. The synthesized 2-chloroquinoline-3-carbaldehyde takes part in a multicomponent reaction with 2-aminopyridine, and isocyanide in the presence of trimethylsilyl chloride. The reaction is facile and the products are synthesized in high isolated yields under mild reaction conditions. © 2021 The Chemical Society Located in Taipei & Wiley-VCH GmbH

Item Type: Article
Keywords: 2-(2-chloroquinolin-3-yl)imidazo1,2-apyridin-3-amine; multicomponent reaction; trimethylsilyl chloride
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > گروه شیمی دارویی
Journal or Publication Title: Journal of the Chinese Chemical Society
Abstract and Indexing: ISI, Scopus
Quartile : Q3
Publisher: Chinese Chemical Society Taiwan
Identification Number: https://doi.org/10.1002/jccs.202000555
ISSN: 00094536
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/7988

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