Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Prevalence of Enterobacteriaceae spp. and its multidrug-resistant rates in clinical isolates: A two-center cross-sectional study

(2021) Prevalence of Enterobacteriaceae spp. and its multidrug-resistant rates in clinical isolates: A two-center cross-sectional study. Molecular Biology Reports. ISSN 03014851

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Enterobacteriaceae spp., owing to their high durability and antibiotic-resistant mechanisms, are described as an eminent part of health treatments in hospital-acquired infections. This study aimed to estimate the prevalence of clinical isolated Enterobacteriaceae spp., and their multidrug-resistant rate in the north of Iran. In this cross-sectional study, over two years (2017�2019), clinical isolates were collected and Enterobacteriaceae spp. were identified using the standard media culture and Analytical Profile Index (API 20E) kit from two centers in the north of Iran. Isolates were confirmed by targeting the rpoB gene. Moreover, the susceptibility patterns of isolates were assessed using disc diffusion methods according to the Clinical Laboratory Standard Institute (CLSI) guidelines. Out of 2645 clinical specimens, 297 (11.2) were confirmed as Enterobacteriaceae spp. containing Eshershia. coli 93 (31), Citrobacter freundii 65 (21.9), Klebsiella pneumoniae 48 (16.2), Enterobacter spp. 43 (14.5), and Proteus spp. 23 (7.7). As much as 8.7 of other spp. Ampicillin (81.1) and cephalexin (80.9) have been shown to have the greatest resistant, and nalidixic acid (65) and amikacin (59.2) were the most sensitive drugs. Multidrug-resistance (MDR) strains are more isolated in the Burn and Burn intensive care unit (BICU) than other wards. The MDR frequency in Bouali and Zareh hospitals were 65 (49.61) and 130 (78.31), respectively. Considering the high isolation rates of MDR Enterobacteriaceae spp., preventive measures need to be taken to remove the mentioned bacteria from hospital wards. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.

Item Type: Article
Keywords: Drug-resistant; Enterobacteriaceae; Hospital-acquired infections; Susceptibility testing
Subjects: QW Microbiology and Immunology > QW 1-300 Microbiology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Microbiology
Journal or Publication Title: Molecular Biology Reports
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Publisher: Springer Science and Business Media B.V.
Identification Number:
ISSN: 03014851
Depositing User: خانم فائزه مظفری

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