Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

A Novel Mesoporous Superparamagnetic Hybrid Silica/Hydroxyapatite Nanocomposite as MRI Contrast Agent

(2021) A Novel Mesoporous Superparamagnetic Hybrid Silica/Hydroxyapatite Nanocomposite as MRI Contrast Agent. ChemNanoMat. ISSN 2199692X

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Abstract

This paper introduces a novel magnetic hybrid silica/hydroxyapatite nanocomposite with a mesoporous structure, MSFeHA. The usefulness of the nanocomposite as an MRI T2 contrast agent was studied. The structure and morphology of the nanocomposite were characterized by FT-IR, XRD, N2 adsorption-desorption isotherms, VSM, TEM, SEM, and EDS-MAP. Then, the biocompatibility of the synthesized nanocomposite was studied by Brine shrimp Artemia lethality assay, red blood cell hemolysis assay, and MTT assay on MCF-7 breast cancer cell line and HFF-2 normal cell line. ICP-OES results indicate that the highest bioaccumulation of MSFeHA nanocomposite has occurred within the liver and, between 4 to 24 hours after administration of MSFeHA. The amount of bioaccumulation within the studied organs decreased over time, which suggests that the nanocomposite biodegradation and excretion process became started. Furthermore, in vitro MRI studies reveal that MSFeHA nanocomposite has the potential to be an MRI T2 contrast agent (r2=106.6 ms). © 2021 Wiley-VCH GmbH

Item Type: Article
Keywords: Bioaccumulation; Biochemistry; Biocompatibility; Biodegradation; Blood; Cell culture; Cells; Silica, Hybrid silica; MCF-7 breast cancer cells; Mesoporous structures; MRI contrast agents; N2 adsorption; Red blood cell hemolysis; Structure and morphology; Superparamagnetics, Nanocomposites
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 100-133 Biochemistry of the Human Body
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacognosy and Pharmaceutical Biotechnology
Journal or Publication Title: ChemNanoMat
Abstract and Indexing: ISI, Scopus
Quartile : Q1
Publisher: Wiley-VCH Verlag
Identification Number: https://doi.org/10.1002/cnma.202000625
ISSN: 2199692X
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/7972

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