Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

(2021) Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications. Advanced Healthcare Materials. ISSN 21922640

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The complexity of hard-to-treat diseases strongly undermines the therapeutic potential of available treatment options. Therefore, a paradigm shift from monotherapy toward combination therapy has been observed in clinical research to improve the efficiency of available treatment options. The advantages of combination therapy include the possibility of synchronous alteration of different biological pathways, reducing the required effective therapeutic dose, reducing drug resistance, and lowering the overall costs of treatment. The tunable physical properties, excellent biocompatibility, facile preparation, and ease of administration with minimal invasiveness of injectable hydrogels (IHs) have made them excellent candidates to solve the clinical and pharmacological limitations of present systems for multitherapy by direct delivery of therapeutic payloads and improving therapeutic responses through the formation of depots containing drugs, genes, cells, or a combination of them in the body after a single injection. In this review, currently available methods for the design and fabrication of IHs are systematically discussed in the first section. Next, as a step toward establishing IHs for future multimodal synergistic therapies, recent advances in cancer combination therapy, wound healing, and tissue engineering are addressed in detail in the following sections. Finally, opportunities and challenges associated with IHs for multitherapy are listed and further discussed. © 2020 Wiley-VCH GmbH

Item Type: Article
Keywords: Biocompatibility; Clinical research; Disease control; Drug dosage; Hydrogels; Medical applications; Tissue regeneration, Biological pathways; Combination therapy; Drug resistance; Facile preparation; Injectable hydrogels; Paradigm shifts; Therapeutic dose; Therapeutic potentials, Diseases
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 100-133 Biochemistry of the Human Body
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacotherapy
Journal or Publication Title: Advanced Healthcare Materials
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 10
Number: 3
Publisher: Wiley-VCH Verlag
Identification Number: https://doi.org/10.1002/adhm.202001571
ISSN: 21922640
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/7962

Actions (login required)

View Item View Item