Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

COVID-19: Virology, biology and novel laboratory diagnosis

(2021) COVID-19: Virology, biology and novel laboratory diagnosis. Journal of Gene Medicine. ISSN 1099498X

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Abstract

Background: At the end of December 2019, a novel coronavirus tentatively named SARS-CoV-2 in Wuhan, a central city in China, was announced by the World Health Organization. SARS-CoV-2 is an RNA virus that has become a major public health concern after the outbreak of the Middle East Respiratory Syndrome-CoV (MERS-CoV) and Severe Acute Respiratory Syndrome-CoV (SARS-CoV) in 2002 and 2012, respectively. As of 29 October 2020, the total number of COVID-19 cases had reached over 44 million worldwide, with more than 1.17 million confirmed deaths. Discussion: SARS-CoV-2 infected patients usually present with severe viral pneumonia. Similar to SARS-CoV, the virus enters respiratory tract cells via the angiotensin-converting enzyme receptor 2. The structural proteins play an essential role in budding the virus particles released from different host cells. To date, an approved vaccine or treatment option of a preventive character to avoid severe courses of COVID-19 is still not available. Conclusions: In the present study, we provide a brief review of the general biological features of CoVs and explain the pathogenesis, clinical symptoms and diagnostic approaches regarding monitoring future infectivity and prevent emerging COVID-19 infections. © 2020 John Wiley & Sons, Ltd.

Item Type: Article
Keywords: coronavirus; diagnostic methods; genome structure; pathogenesis
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
WC Communicable Diseases > WC 500-590 Virus Diseases
Journal or Publication Title: Journal of Gene Medicine
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 23
Number: 2
Publisher: Blackwell Publishing Inc.
Identification Number: https://doi.org/10.1002/jgm.3303
ISSN: 1099498X
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/7956

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