Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Microneedles for painless transdermal immunotherapeutic applications

(2021) Microneedles for painless transdermal immunotherapeutic applications. Journal of Controlled Release. pp. 185-217. ISSN 01683659

Full text not available from this repository. (Request a copy)

Official URL:


Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in the treatment of various diseases. However, owing to the dynamic nature of the immune system, this approach has often been challenged by concerns regarding the lack of adequate long-term responses in patients. The development of microneedles (MNs) has resulted in the improvement and expansion of immuno-reprogramming strategies due to the housing of high accumulation of dendritic cells, macrophages, lymphocytes, and mast cells in the dermis layer of the skin. In addition, MNs possess many outstanding properties, such as the ability for the painless traverse of the stratum corneum, minimal invasiveness, facile fabrication, excellent biocompatibility, convenient administration, and bypassing the first pass metabolism that allows direct translocation of therapeutics into the systematic circulation. These advantages make MNs excellent candidates for the delivery of immunological biomolecules to the dermal antigen-presenting cells in the skin with the aim of vaccinating or treating different diseases, such as cancer and autoimmune disorders, with minimal invasiveness and side effects. This review discusses the recent advances in engineered MNs and tackles limitations relevant to traditional immunotherapy of various hard-to-treat diseases. © 2020 Elsevier B.V.

Item Type: Article
Keywords: Biocompatibility; Needles, Antigen presenting cells; Autoimmune disorder; Clinical outcome; Dendritic cells; Dynamic nature; Facile fabrication; Immunotherapeutic; Stratum corneum, Diseases, bacterial vaccine; cancer vaccine; DNA vaccine; immunomodulating agent; virus vaccine, acne; antigen presenting cell; Article; atopic dermatitis; autoimmune disease; biocompatibility; cancer immunotherapy; clinical outcome; dendritic cell; dermis; drug delivery system; first pass effect; food allergy; human; immunotherapy; insulin dependent diabetes mellitus; lymphocyte; macrophage; mast cell; nonhuman; outcome assessment; physical chemistry; priority journal; psoriasis; respiratory tract allergy; rheumatoid arthritis; stratum corneum; vaccination; wound healing
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QW Microbiology and Immunology > QW 501-949 Immunology
QZ Pathology > QZ 200-380 Neoplasms
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacotherapy
Page Range: pp. 185-217
Journal or Publication Title: Journal of Controlled Release
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 330
Publisher: Elsevier B.V.
Identification Number:
ISSN: 01683659
Depositing User: خانم فائزه مظفری

Actions (login required)

View Item View Item