Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Effects of vitamin E and selenium on allergic rhinitis and asthma pathophysiology

(2021) Effects of vitamin E and selenium on allergic rhinitis and asthma pathophysiology. Respiratory Physiology and Neurobiology. ISSN 15699048

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Abstract

Allergic diseases such as asthma and rhinitis are common health problems that affect hundreds of millions of people in the world. T helper 2 cytokines participate in the immune responses in these diseases. Vitamin E and selenium (Se) are supplementary factors which have immunomodulatory and antioxidant effects. The present study investigated the effects of vit E + Se administration on allergic symptoms in mice models of asthma and rhinitis. Mice were treated with vit E and Se, and the levels of IL-4, IL-5, IL-13, IL-25, IL-33, total IgE, and histamine were measured. Lung histopathology was also analyzed. Our results indicated that vit E could attenuate allergic rhinitis and asthma symptoms; nevertheless, treatment with Se alone was not effective in controlling allergic symptoms. We noticed reduced airway inflammation and constriction and mucus secretion in the mice, especially when vit E was used in combination with Se. Our result suggested that vit E, especially in combination with Se, could control allergic mediators and symptoms in rhinitis and asthma and reduce pulmonary inflammation and airway mucus secretion, helping to open obstructed bronchi. © 2021 Elsevier B.V.

Item Type: Article
Keywords: Allergy; Inflammation; Oxidative stress; Selenium; Vitamin E
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Immunology Department
Journal or Publication Title: Respiratory Physiology and Neurobiology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 286
Publisher: Elsevier B.V.
Identification Number: https://doi.org/10.1016/j.resp.2020.103614
ISSN: 15699048
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/7944

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