(2016) Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis- -related genes in diabetic rats. Bratislava Medical Journal. pp. 472-479.
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Abstract
Memory impairment is a common disorder in diabetes mellitus which is associated with hippocampal neuronal apoptosis. The present study was conducted to examine the effect of one-week intraperitoneal (ip), administration of aminoguanidine (AG) on passive avoidance learning (PAL) and Bcl-2 family gene expression in the hippocampus of rats. Sixty male rats were divided into ten groups: non-diabetic/diabetic animals with/without AG (50, 100, 200 and 400 mg/kg, ip) treatment for one week. PAL and Bcl-2 family genes were examined. AG (100 and 200 mg/kg) improved both memory and Bax, Bak, Bcl-2 and Bcl-xl deficiency significantly in diabetic rats. AG treatment also ameliorated the diabetes-induced changes in (Bcl-2+Bcl-xl)/(Bak+Bax) ratios considerably. These results propose that one-week ip administration of AG may recover the deficit cognition in diabetic rats via enhancing (Bcl-2+Bcl-xl)/(Bak+Bax) proportions.
| Item Type: | Article |
|---|---|
| Keywords: | Aminoguanidine Bcl-2 family genes Diabetes mellitus Passive avoidance learning Rats apoptosis regulatory protein guanidine derivative protein Bax protein bcl 2 protein bcl x animal apoptosis avoidance behavior biosynthesis drug effects experimental diabetes mellitus hippocampus intraperitoneal drug administration male memory metabolism physiology randomization rat Wistar rat Animals Apoptosis Regulatory Proteins Avoidance Learning bcl-2-Associated X Protein bcl-X Protein Diabetes Mellitus, Experimental Guanidines Injections, Intraperitoneal Proto-Oncogene Proteins c-bcl-2 Random Allocation Rats, Wistar |
| Page Range: | pp. 472-479 |
| Journal or Publication Title: | Bratislava Medical Journal |
| Abstract and Indexing: | ISI, Pubmed, Scopus |
| Quartile : | Q4 |
| Volume: | 117 |
| Number: | 8 |
| Identification Number: | https://doi.org/10.4149/BLL₂₀₁₆₀₉₂ |
| Depositing User: | خانم مریم زرقانی |
| URI: | http://repository.zums.ac.ir/id/eprint/783 |
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