Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis- -related genes in diabetic rats

(2016) Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis- -related genes in diabetic rats. Bratislava Medical Journal. pp. 472-479.

Full text not available from this repository. (Request a copy)

Official URL: http://apps.webofknowledge.com/full_record.do?prod...

Abstract

Memory impairment is a common disorder in diabetes mellitus which is associated with hippocampal neuronal apoptosis. The present study was conducted to examine the effect of one-week intraperitoneal (ip), administration of aminoguanidine (AG) on passive avoidance learning (PAL) and Bcl-2 family gene expression in the hippocampus of rats. Sixty male rats were divided into ten groups: non-diabetic/diabetic animals with/without AG (50, 100, 200 and 400 mg/kg, ip) treatment for one week. PAL and Bcl-2 family genes were examined. AG (100 and 200 mg/kg) improved both memory and Bax, Bak, Bcl-2 and Bcl-xl deficiency significantly in diabetic rats. AG treatment also ameliorated the diabetes-induced changes in (Bcl-2+Bcl-xl)/(Bak+Bax) ratios considerably. These results propose that one-week ip administration of AG may recover the deficit cognition in diabetic rats via enhancing (Bcl-2+Bcl-xl)/(Bak+Bax) proportions.

Item Type: Article
Keywords: Aminoguanidine Bcl-2 family genes Diabetes mellitus Passive avoidance learning Rats apoptosis regulatory protein guanidine derivative protein Bax protein bcl 2 protein bcl x animal apoptosis avoidance behavior biosynthesis drug effects experimental diabetes mellitus hippocampus intraperitoneal drug administration male memory metabolism physiology randomization rat Wistar rat Animals Apoptosis Regulatory Proteins Avoidance Learning bcl-2-Associated X Protein bcl-X Protein Diabetes Mellitus, Experimental Guanidines Injections, Intraperitoneal Proto-Oncogene Proteins c-bcl-2 Random Allocation Rats, Wistar
Page Range: pp. 472-479
Journal or Publication Title: Bratislava Medical Journal
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 117
Number: 8
Identification Number: https://doi.org/10.4149/BLL₂₀₁₆₀₉₂
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/783

Actions (login required)

View Item View Item