Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Synthesis and therapeutic potential of stimuli-responsive metal-organic frameworks

(2021) Synthesis and therapeutic potential of stimuli-responsive metal-organic frameworks. Chemical Engineering Journal. ISSN 1385-8947, 1873-3212

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Nanotechnology, as a progressing field of science, is constantly expanding its role in biomedicine by introducing novel nanoplatforms over time. Nanoscaled metal-organic frameworks (NMOFs) are porous hybrid solids made of organic ligands and metal ions that offer a powerful potential to revolutionize traditional nanocarriers due to their tunable structural features, high surface area, adjustable pore size, facile synthesis, biocompatibility, highly versatile composition, and high chemical stability. Among various types of NMOFs, the stimuli-responsive ones are efficient candidates for biomedical applications, because they are designed to specifically change their property upon exposure to interior stimuli in target tissues (e.g., pH and redox reaction triggering agents), or external stimuli like temperature, light, and magnetic field. In this review, to fully address recent advances in the field of stimuli-responsive MOF nanocarriers, we have present the basic chemistry behind the stimuli-responsive mechanisms of MOFs. In addition, recent progresses on MOF-based stimuli-responsive systems, including those responding to a single stimulus and multiple stimuli, are discussed, providing an innovative vision for the design of multifunctional smart MOFs that can respond to different triggers. © 2020 Elsevier B.V.

Item Type: Article
Keywords: Adjustable pore size,Biocompatibility,Biomedical applications,Cancer therapy,Chelation,Chemical stability,Drug delivery,External stimulus,Light-responsive,Medical applications,Metal ions,Metal-Organic Frameworks,Metal-organic framework,Metals,Nano-scaled metals,Organic polymers,Organometallics,Pore size,Redox reactions,Redox-responsive,Stimuli-responsive,Stimuli-responsive systems,Structural feature,Temperature-responsive,Therapeutic potentials,pH-responsive
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QZ Pathology > QZ 200-380 Neoplasms
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacotherapy
Journal or Publication Title: Chemical Engineering Journal
Abstract and Indexing: ISI, Scopus
Quartile : Q1
Number: 408
Publisher: Elsevier B.V.
Identification Number:
ISSN: 1385-8947, 1873-3212
ISBN: 13858947 (ISSN)
Depositing User: خانم فائزه مظفری

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