Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Biotechnological and biomedical applications of mesenchymal stem cells as a therapeutic system

(2016) Biotechnological and biomedical applications of mesenchymal stem cells as a therapeutic system. Artificial cells, nanomedicine, and biotechnology. pp. 559-70. ISSN 2169-141X (Electronic) 2169-1401 (Linking)

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Abstract

Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent progenitor cells which reside in bone marrow (BM), support homing of hematopoietic stem cells (HSCs) and self-renewal in the BM. These cells have the potential to differentiate into tissues of mesenchymal origin, such as fibroblasts, adipocytes, cardiomyocytes, and stromal cells. MSCs can express surface molecules like CD13, CD29, CD44, CD73, CD90, CD166, CXCL12 and toll-like receptors (TLRs). Different factors, such as TGF-beta, IL-10, IDO, PGE-2, sHLA-G5, HO, and Galectin-3, secreted by MSCs, induce interaction in cell to cell immunomodulatory effects on innate and adaptive cells of the immune system. Furthermore, these cells can stimulate and increase the TH2 and regulatory T-cells through inhibitory effects on the immune system. MSCs originate from the BM and other tissues including the brain, adipose tissue, peripheral blood, cornea, thymus, spleen, fallopian tube, placenta, Wharton's jelly and umbilical cord blood. Many studies have focused on two significant features of MSC therapy: (I) MSCs can modulate T-cell-mediated immunological responses, and (II) systemically administered MSCs home in to sites of ischemia or injury. In this review, we describe the known mechanisms of immunomodulation and homing of MSCs. As a result, this review emphasizes the functional role of MSCs in modulating immune responses, their capability in homing to injured tissue, and their clinical therapeutic potential.

Item Type: Article
Keywords: Adaptive Immunity Animals Biotechnology/*methods Cell- and Tissue-Based Therapy/*methods Humans Immunity, Innate Immunomodulation *Mesenchymal Stromal Cells/cytology/immunology bone marrow cells immune system immunomodulatory mesenchymal stem cells
Page Range: pp. 559-70
Journal or Publication Title: Artificial cells, nanomedicine, and biotechnology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 44
Number: 2
Identification Number: https://doi.org/10.3109/21691401.2014.968823
ISSN: 2169-141X (Electronic) 2169-1401 (Linking)
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/724

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