Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Multidirectional Strategies for Targeted Delivery of Oncolytic Viruses by Tumor Infiltrating Immune Cells

(2020) Multidirectional Strategies for Targeted Delivery of Oncolytic Viruses by Tumor Infiltrating Immune Cells. Pharmacol Res. ISSN 1043-6618, 1096-1186

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Official URL: https://www.sciencedirect.com/science/article/abs/...

Abstract

Oncolytic virus (OV) immunotherapy has demonstrated to be a promising approach in cancer treatment due to tumor-specific oncolysis. However, their clinical use so far has been largely limited due to the lack of suitable delivery strategies with high efficacy. Direct â��intratumoral' injection is the way to cross the hurdles of systemic toxicity, while providing local effects. Progress in this field has enabled the development of alternative way using â��systemic' oncolytic virotherapy for producing better results. One major potential roadblock to systemic OV delivery is the low virus persistence in the face of hostile immune system. The delivery challenge is even greater when attempting to target the oncolytic viruses into the entire tumor mass, where not all tumor cells are equally exposed to exactly the same microenvironment. The microenvironment of many tumors is known to be massively infiltrated with various types of leucocytes in both primary and metastatic sites. Interestingly, this intratumoral immune cell heterogeneity exhibits a degree of organized distribution inside the tumor bed as evidenced, for example, by the hypoxic tumor microenviroment where predominantly recruits tumor-associated macrophages. Although in vivo OV delivery seems complicated and challenging, recent results are encouraging for decreasing the limitations of systemically administered oncolytic viruses and an improved efficiency of oncolytic viral therapy in targeting cancerous tissues in vitro. Here, we review the latest developments of carrier cell-based oncolytic virus delivery using tumor-infiltrating immune cells with a focus on the main features of each cellular vehicle. © 2020 Elsevier Ltd

Item Type: Article
Keywords: CAR-T cell,Cytokine-induced killer (CIK) cell,Immune carrier cells,MDSC,Oncolytic virotherapy,Tumor infiltrating leukocytes (TILs)
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Immunology Department
Journal or Publication Title: Pharmacol Res
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 161
Publisher: Academic Press
Identification Number: https://doi.org/10.1016/j.phrs.2020.105094
ISSN: 1043-6618, 1096-1186
ISBN: 10436618 (ISSN)
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/7197

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