Abstract

AIMS: The present study was carried out to determine the optimal cutoff points for homeostatic model assessment (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) in the diagnosis of metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD). METHODS: The baseline data of 5511 subjects aged >/=18years of a cohort study in northern Iran were utilized to analyze. Receiver operating characteristic (ROC) analysis was conducted to determine the discriminatory capability of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. Youden index was utilized to determine the optimal cutoff points of HOMA-IR and QUICKI in the diagnosis of MetS and NAFLD. RESULTS: The optimal cutoff points for HOMA-IR in the diagnosis of MetS and NAFLD were 2.0 sensitivity=64.4%, specificity=66.8% and 1.79 sensitivity=66.2%, specificity=62.2% in men and were 2.5 sensitivity=57.6%, specificity=67.9% and 1.95 sensitivity=65.1%, specificity=54.7% in women respectively. Furthermore, the optimal cutoff points for QUICKI in the diagnosis of MetS and NAFLD were 0.343 sensitivity=63.7%, specificity=67.8% and 0.347 sensitivity=62.9%, specificity=65.0% in men and were 0.331 sensitivity=55.7%, specificity=70.7% and 0.333 sensitivity=53.2%, specificity=67.7% in women respectively. CONCLUSION: Not only the optimal cutoff points of HOMA-IR and QUICKI were different for MetS and NAFLD, but also different cutoff points were obtained for men and women for each of these two conditions.