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دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): A systematic review and meta-analysis

(2020) The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): A systematic review and meta-analysis. BMC Cardiovasc Disord. ISSN 1471-2261

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Official URL: https://pubmed.ncbi.nlm.nih.gov/32429880/

Abstract

Background: We performed a systematic review and meta-analysis of the Matrix metalloproteinases (MMP)-9 (C1562T), MMP-9 (R279Q), MMP-9 (P574R) and MMP-9 (R668Q) polymorphisms and risk of Coronary Artery Disease (CAD). Methods: After a systematic literature search, pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were used to evaluate the strength of the association. Results: We identified 40 studies with 11,792 cases and 8280 controls for C1562T, 7 case-control studies with 5525 cases and 2497 controls for R279Q, 2 studies with 1272 cases and 785 controls for P574R, and 2 studies with 1272 cases and 785 controls for R668Q. MMP-9 (C1562T) polymorphism was associated with increased risk of CAD under dominant model (OR = 1.41, P \textless 0.001), recessive model (OR = 1.59, P \textless 0.001), allelic model (OR = 1.38, P \textless 0.001), TT vs. CC model (OR = 1.70, P \textless 0.001), and CT vs. CC model (OR = 1.35, P \textless 0.001). Moreover, the subgroup analysis based on the continent of the study populations in this SNP indicated strong significant association in Asians but not in Europeans. Subgroup analysis was not performed in Africa, America and Oceania, due to lack of sufficient data. Conclusions: Our meta-analysis revealed that MMP-9 (C1562T) SNP conferred a susceptibility risk for CAD in the overall analysis and Asian population. The overall analysis and subgroup analysis of the other three SNPs reject the association between MMP-9 polymorphisms and the risk of CAD. Although the results should interpret with caution because of small sample size of included studies in these three SNPs. © 2020 The Author(s).

Item Type: Article
Keywords: Article,Asian,Coronary artery disease,Genetic polymorphism,MMP 9 gene,Matrix metalloproteinases,Meta-analysis,cardiovascular risk,clinical evaluation,gelatinase B,genetic association,genetic susceptibility,genotype,human,polymerase chain reaction restriction fragment length polymorphism,priority journal,sample size,single nucleotide polymorphism,systematic review
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Cardiovascular System > WG 120-180 Cardiovascular Diseases, Diagnosis, and Therapeutics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Cardiology
Journal or Publication Title: BMC Cardiovasc Disord
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 20
Number: 1
Publisher: BioMed Central Ltd.
Identification Number: https://doi.org/10.1186/s12872-020-01510-4
ISSN: 1471-2261
ISBN: 14712261 (ISSN)
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/7160

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