Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Imidazole-Functionalized Ag/MOFs as Promising Scaffolds for Proper Antibacterial Activity and Toxicity Reduction of Ag Nanoparticles

(2020) Imidazole-Functionalized Ag/MOFs as Promising Scaffolds for Proper Antibacterial Activity and Toxicity Reduction of Ag Nanoparticles. Journal of Inorganic and Organometallic Polymers and Materials. ISSN 1574-1443,

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Official URL: https://link.springer.com/article/10.1007/s10904-0...

Abstract

Microbial contamination control is one of the most important demands in most industries and hospitals. Among vast antimicrobial groups, silver nanoparticles are desirable due to their great antibacterial properties, whereas the toxic effect of silver on animal and human cells cannot be neglected. In this study, the cytotoxicity of the new silver/imidazole was investigated in a metal framework (MOF) composition. Lung epithelial cells (A549) were cultured at 37 ºC in 5% CO2. The cytotoxicity of six types of particles/material (i.e., AgNO3, MIL-101(Cr)/IMI, Imidazole, Ag/MIL-101(Cr), Ag/MIL-101(Cr)/IMI, and MIL-101(Cr)) was examined by MTT assay. Also, the doseâ��response curves were plotted using Graphpad Prism. The minimum inhibitory concentration (MIC) was determined for E. coli and S. aureus. Based on the doseâ��response curves, AgNO3 (IC50 = 17.39 μg/mL) and MIL-101(Cr) (IC50 = 158.2 μg/mL) were the most and less toxic substances, respectively. However, the antibacterial property of Ag/MIL-101(Cr)/IMI was desired with less cell toxicity (IC50 = 140.4 μg/mL) in comparison with AgNO3. Although the new metal framework of Ag/imidazole allowed the composition particles to act as a great antibacterial, it reduced the metal leaching from the composition. Accordingly, less Ag leaching would lead to lower human cell toxicity. On the other hand, this framework would increase its disinfection efficiency in comparison with other substances. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Item Type: Article
Keywords: A549 cells,Anti-bacterial activity,Antibacterial,Antibacterial properties,Cells,Chromium compounds,Cytology,Cytotoxicity,Disinfection efficiency,Escherichia coli,Imidazole,Leaching,Lung epithelial cells,Metal nanoparticles,Microbial contamination,Minimum inhibitory concentration,Silver,Silver compounds,Silver nanoparticles,Toxic substances,Toxicity,Toxicity reduction
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QV Pharmacology > QV 350-370 Anti-Bacterial Agents. Tissue Extracts
Divisions: Education Vice-Chancellor Department > Faculty of Health > Department of Occupational Health
Journal or Publication Title: Journal of Inorganic and Organometallic Polymers and Materials
Abstract and Indexing: ISI, Scopus
Quartile : Q2
Publisher: Springer
Identification Number: https://doi.org/10.1007/s10904-020-01612-8
ISSN: 1574-1443,
ISBN: 15741443 (ISSN)
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/7155

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