Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Nandrolone decanoate negatively reverses the beneficial effects of exercise on cardiac muscle via sarcolemmal, but not mitochondrial K(ATP) channel

(2016) Nandrolone decanoate negatively reverses the beneficial effects of exercise on cardiac muscle via sarcolemmal, but not mitochondrial K(ATP) channel. Canadian Journal of Physiology and Pharmacology. pp. 324-31. ISSN 1205-7541 (Electronic) 0008-4212 (Linking)

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Abstract

ATP-sensitive potassium channels are supposed to have a substantial role in improvement of cardiac performance. This study was performed to evaluate whether nandrolone decanoate (ND) and (or) exercise training could affect the expression of cardiac K(ATP) channel subunits. Thirty-five male albino Wistar rats were randomly divided into 5 groups, including sedentary control (SC), sedentary vehicle (SV), sedentary ND (SND), exercise control (EC), and exercise and ND (E+ND). Exercise training was performed on a treadmill 5 times per week. ND was injected (10 mg/kg/week, i.m.) to the rats in the SND and E+ND groups. Following cardiac isolation, the expression of both sarcolemmal and mitochondrial subunits of K(ATP) channel was measured using Western blot method. The expression of sarcolemmal, but not mitochondrial, subunits of K(ATP) channel (Kir6.2 and SUR2) of EC group was significantly higher compared with SC group while ND administration (SND group) did not show any change in their expression. In the E+ND group, ND administration led to decrease of the over-expression of sarcolemmal Kir6.2 and SUR2 which was previously induced by exercise. There was no significant association between the mitochondrial expression of either Kir6.2 or SUR2 proteins and administration of ND or exercise. Supra-physiological dosage of ND negatively reverses the effects of exercise on the cardiac muscle expression of sarcolemmal, but not mitochondrial, K(ATP) channel subunits.

Item Type: Article
Keywords: ATP-Binding Cassette Transporters/metabolism Adenosine Triphosphate/metabolism Animals Heart/drug effects KATP Channels/*metabolism Male Mitochondria/*drug effects/metabolism Myocardium/*metabolism Nandrolone/*analogs & derivatives/pharmacology Physical Conditioning, Animal/*physiology Potassium Channels/*metabolism Potassium Channels, Inwardly Rectifying/metabolism Rats Rats, Wistar Sarcolemma/*drug effects/metabolism KATP channel Kir6.2 Sur2 canal KATP decanoate de nandrolone entrainement physique exercise mitochondria mitochondrie nandrolone decanoate sarcolemma sarcolemme
Page Range: pp. 324-31
Journal or Publication Title: Canadian Journal of Physiology and Pharmacology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 94
Number: 3
Identification Number: https://doi.org/10.1139/cjpp-2015-0040
ISSN: 1205-7541 (Electronic) 0008-4212 (Linking)
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/712

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