Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Preparation, optimization and characterization of chitosancoated liposomes for solubility enhancement of furosemide: A model BCS IV drug

(2020) Preparation, optimization and characterization of chitosancoated liposomes for solubility enhancement of furosemide: A model BCS IV drug. Iranian Journal of Pharmaceutical Research. pp. 366-382. ISSN 17350328

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Official URL: http://ijpr.sbmu.ac.ir/article_1101009.html

Abstract

Most of the drugs are administered orally and they must be absorbed from gastrointestinal tract for systemic effect. Generally, drug molecules get dissolved in GI fluids before absorption. Solubility and permeability of drugs are considered as two parameters in biopharmaceutical classification system (BCS). Many researches were performed to change permeability and solubility of the drugs to improve abruption and bioavailability of them. Lipidic nanocarriers such as nanoliposomes are one approach to dissolve poorly water soluble drugs. Furosemide (FMD) as a typical molecule in BCS IV has low solubility and permeability. Thermodynamically, molecules of FMD could stay in the space of liposomal membrane. In this study effective parameters to preparation of nanoliposomes coated by chitosan (CCLs) were screened optimized by experimental design. Particle size, polydispersity index, and surface potential of optimized CCLs have 155.8 ± 3.5 nm, 0.229 ± 0.022, and 25.2 ± 3.5 mV, respectively. FMD was loaded in optimized CCLs 98.94 ± 0.7. Size of CCLs have verified by atomic force electron microscope. CCLs loaded by FMD were dried and in-vitro study was performed to test release of FMD from powder. Results demonstrated that solubility and dissolution of FMD increased by loading in CCLs in comparison to crystalline FMD and physical mixture of FMD and materials of CCLs. © 2020, Iranian Journal of Pharmaceutical Research. All rights reserved.

Item Type: Article
Keywords: acteoside; alcohol; carotenoid; chitosan; cisplatin; cyclodextrin; furosemide; ghrelin; liposome; maltodextrin; metronidazole; nanoparticle; phosphatidylcholine; polyvinyl alcohol; superoxide dismutase, Article; atomic force microscopy; body surface potential; crystallization; differential scanning calorimetry; drug absorption; drug bioavailability; drug classification; drug delivery system; drug formulation; drug penetration; drug release; drug solubility; encapsulation; high performance liquid chromatography; in vitro study; lipophilicity; microfiltration; nanoencapsulation; particle size; process optimization; reaction optimization; spray drying; stomach juice; stomach pH; tablet friability; tablet hardness; tapped density; thermal analysis; zeta potential
Subjects: QV Pharmacology > QV 701-835 Pharmacy and Pharmaceutics
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacognosy and Pharmaceutical Biotechnology
Page Range: pp. 366-382
Journal or Publication Title: Iranian Journal of Pharmaceutical Research
Abstract and Indexing: ISI, Pubmed, Scopus, Other
Quartile : Q4
Volume: 19
Number: 1
Publisher: Iranian Journal of Pharmaceutical Research
Identification Number: https://doi.org/10.22037/ijpr.2019.111834.13384
ISSN: 17350328
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/6986

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