Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Evaluation radioprotective effect of curcumin conjugated albumin nanoparticles.

(2020) Evaluation radioprotective effect of curcumin conjugated albumin nanoparticles. Bioorganic chemistry. p. 103891. ISSN 1090-2120 (Electronic)

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Official URL: https://pubmed.ncbi.nlm.nih.gov/32422388/

Abstract

In this research, curcumin (CUR) conjugated albumin based nanoparticles (BSA-CUR) were designed for improvement and evaluation radioprotective effect of CUR. In this way, we have prepared BSA-CUR by covalently binding the CUR with BSA. Next, this synthesized prodrug was evaluated for physical and chemical properties by Fourier-transform infrared (FTIR), Dynamic light scattering (DLS), Transmission electron microscopy (TEM), Ultraviolet-visible (UV/Vis), and Differential scanning calorimetry (DSC) analysis. Furthermore, the chemical stability of designed prodrug was appraised. The result shows that the size of nanoparticles is 174.4 nm with a polydispersity index (PdI) of 0.191. The nanoparticles have a high loading capacity and show sustained release behavior. Loading of CUR to BSA not only could increase the chemical stability of CUR, but also could improve radioprotection efficacy of it's against X-Ray irradiation. The HHF-2 cells show 107% viability in the presence of BSA-CUR at a concentration of 50 µg/mL, whereas non-treated cells show 46% viability, under X-Ray irradiation. Also in vivo study results show that, four out of five mice have died when the mice irradiated by X-Ray and no received any treatment. Although, for a group that treated with BSA-CUR and also irradiated by X-Ray, median survival and survival rate was higher than CUR treated and control mice, and only two out of five mice have died. The result of this study proved that BSA-CUR can be used as a proficient vehicle for improving the potential radioprotective effect of CUR.

Item Type: Article
Keywords: BSA; Curcumin; Drug conjugate; Radioprotection; X-Ray irradiation
Subjects: WN Radiology. Diagnostic Imaging > WN 180-240 Diagnostic Imaging
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacotherapy
Page Range: p. 103891
Journal or Publication Title: Bioorganic chemistry
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 100
Publisher: Elsevier
Identification Number: https://doi.org/10.1016/j.bioorg.2020.103891
ISSN: 1090-2120 (Electronic)
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/6941

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