Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Development and characterization of a novel lipohydrogel nanocarrier: repaglinide as a lipophilic model drug

(2016) Development and characterization of a novel lipohydrogel nanocarrier: repaglinide as a lipophilic model drug. The Journal of pharmacy and pharmacology. pp. 450-8. ISSN 2042-7158 (Electronic) 0022-3573 (Linking)

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Abstract

OBJECTIVES: Solid lipid nanoparticles (SLNs) are highly susceptible to phagocytosis by reticuloendothelial system (RES). To overcome this problem, a novel hydrogel-coated SLNs structure was developed and evaluated in this study. METHODS: Solid lipid nanoparticles surface was coated with chitosan, via electrostatic attraction with the negatively charged SLNs surface. The resulting polymer-coated SLNs then hosted an inorganic poly-anionic agent, tripolyphosphate, to form the final lipohydrogel structure. KEY FINDINGS: Compared with the bare SLNs, lipohydrogel nanoparticles (LHNs) showed a significant increase in size and zeta potential. The release profile showed lower burst release and lower release rate for LHNs compared with SLNs. LHNs nanoparticles released the model antidiabetic drug, repaglinide, in a more sustained manner with lower burst effect compared with the corresponding SLN structure. Cytotoxicity studies via cell culture and MTT assay revealed no bio-toxicity of the SLNs and LHNs. In addition, intravenous administration of repaglinide-loaded SLNs and LHNs in rats showed longer drug residence time in circulation for LHNs, a trend also evident for the blood glucose level-time profile. CONCLUSION: The particle size, zeta potential, FTIR and microscopy data demonstrated the formation of the supposed lipohydrogel nanoparticles. All these benefits of LHNs propose it as a promising candidate for controlled release of the drugs.

Item Type: Article
Keywords: Administration, Intravenous Animals Blood Glucose/drug effects/metabolism Carbamates/administration & dosage/*chemistry/pharmacokinetics/toxicity Cell Line Cell Survival/drug effects Chitosan/chemistry Delayed-Action Preparations *Drug Carriers Drug Compounding Fibroblasts/drug effects/pathology Hydrogels Hypoglycemic Agents/administration & dosage/*chemistry/pharmacokinetics/toxicity Lipids/*chemistry/toxicity Male Mice Nanotechnology Particle Size Piperidines/administration & dosage/*chemistry/pharmacokinetics/toxicity Polyphosphates/chemistry Rats, Sprague-Dawley Solubility Spectroscopy, Fourier Transform Infrared Static Electricity Surface Properties Technology, Pharmaceutical/methods *chitosan *lipohydrogel *nanocarrier *repaglinide *solid lipid nanoparticles
Page Range: pp. 450-8
Journal or Publication Title: The Journal of pharmacy and pharmacology
Abstract and Indexing: Pubmed, Scopus
Quartile : Q3
Volume: 68
Number: 4
Identification Number: https://doi.org/10.1111/jphp.12537
ISSN: 2042-7158 (Electronic) 0022-3573 (Linking)
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/693

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