Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Maternal death due to COVID-19.

(2020) Maternal death due to COVID-19. American journal of obstetrics and gynecology. 109.e1-109.e16. ISSN 1097-6868 (Electronic)

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Abstract

BACKGROUND: Despite 2.5 million infections and 169,000 deaths worldwide (as of April 20, 2020), no maternal deaths and only a few pregnant women afflicted with severe respiratory morbidity have been reported to be related to COVID-19 disease. Given the disproportionate burden of severe and fatal respiratory disease previously documented among pregnant women following other coronavirus-related outbreaks (SARS-CoV in 2003 and MERS-CoV in 2012) and influenza pandemics over the last century, the absence of reported maternal morbidity and mortality with COVID-19 disease is unexpected. OBJECTIVE: To describe maternal and perinatal outcomes and death in a case series of pregnant women with COVID-19 disease. STUDY DESIGN: We describe here a multiinstitution adjudicated case series from Iran that includes 9 pregnant women diagnosed with severe COVID-19 disease in their second or third trimester. All 9 pregnant women received a diagnosis of SARS-CoV-2 infection by reverse transcription polymerase chain reaction nucleic acid testing. Outcomes of these women were compared with their familial/household members with contact to the affected patient on or after their symptom onset. All data were reported at death or after a minimum of 14 days from date of admission with COVID-19 disease. RESULTS: Among 9 pregnant women with severe COVID-19 disease, at the time of reporting, 7 of 9 died, 1 of 9 remains critically ill and ventilator dependent, and 1 of 9 recovered after prolonged hospitalization. We obtained self-verified familial/household cohort data in all 9 cases, and in each and every instance, maternal outcomes were more severe compared with outcomes of other high- and low-risk familial/household members (n=33 members for comparison). CONCLUSION: We report herein maternal deaths owing to COVID-19 disease. Until rigorously collected surveillance data emerge, it is prudent to be aware of the potential for maternal death among pregnant women diagnosed as having COVID-19 disease in their second or third trimester.

Item Type: Article
Keywords: coronavirus disease in pregnancy; COVID-19; lower respiratory infections in pregnancy; maternal death; maternal mortality; maternal respiratory morbidity; pregnancy; respiratory failure with COVID-19; SARS CoV-2 virus
Subjects: QW Microbiology and Immunology > QW 1-300 Microbiology
WQ Obstetrics > WQ 215-270 Pregnancy Complications
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Obstetrics and Gynecology
Page Range: 109.e1-109.e16
Journal or Publication Title: American journal of obstetrics and gynecology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 223
Number: 1
Publisher: ClinicalKey, Elsever
Identification Number: https://doi.org/10.1016/j.ajog.2020.04.030
ISSN: 1097-6868 (Electronic)
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/6889

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