Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Mesenchymal Stem Cells: A New Generation of Therapeutic Agent Vehicles in Gene Therapy.

(2020) Mesenchymal Stem Cells: A New Generation of Therapeutic Agent Vehicles in Gene Therapy. Current gene therapy. ISSN 1875-5631 (Electronic)

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In recent years, mesenchymal stem cells (MSCs) as a new tool for therapeutic gene delivery in clinics have attracted much attention. Its advantages contain longer lifespan, better isolation, and higher transfection efficiency and proliferation rate. MSCs are the preferred approach for cell-based therapies because of their in vitro self-renewal capacity, migrating especially to tumor tissues, as well as anti-inflammatory and immunomodulatory properties. Therefore, they have considerable efficiency in genetic engineering for future clinical applications in cancer gene therapy and other diseases. For improving in therapeutic efficiency, targeted therapy of cancers can be achieved through sustained release of therapeutic agents and functional gene expression induction to the intended tissues. The development of a new vector in gene therapy can improve the durability of transgene expression. Also, the safety of the vector if administered systemically may resolve several problems, such as durability of expression and the host immune response. Currently, MSCs are prominent candidates as cell vehicles for both preclinical and clinical trials due to the secretion of therapeutic agents in several cancers. In the present study, we discuss the status of gene therapy in both viral and non-viral vectors along with their limitations. Throughout this study, the use of several nano-carriers for gene therapy was also investigated. Finally, we critically discuss the promising advantages of MSCs in targeted gene delivery, tumor inhibition and their utilization as the gene carriers in clinical situations.

Item Type: Article
Keywords: Gene therapy; mesenchymal stem cells; nano-carrier vectors
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Journal or Publication Title: Current gene therapy
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Identification Number:
ISSN: 1875-5631 (Electronic)
Depositing User: خانم فائزه مظفری

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