Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

No evidence of occult HBV infection in population born after mass vaccination.

(2020) No evidence of occult HBV infection in population born after mass vaccination. Wiener medizinische Wochenschrift (1946). pp. 218-223. ISSN 1563-258X (Electronic)

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Official URL: https://pubmed.ncbi.nlm.nih.gov/32274600/

Abstract

Despite access to efficient hepatitis B virus (HBV) vaccine and universal immunization schedules, HBV infection remains a global health concern. HBV infection has decreased by this program. Nevertheless, breakthrough infections occur due to generation of occult HBV infection (OBI) and surface gene mutants in the immunized population. We aimed to determine the presence of OBI in a population born after initiation of nationwide HBV vaccination in Tehran, Iran. A HBV mass vaccination schedule was launched in Iran in 1993. For this study, we enrolled 1120 cases younger than 24 years. ELISA was applied to evaluate the presence of HBsAg, anti-HBs and anti-HBc. HBV-DNA presence was determined in all HBsAg-negative cases using nested polymerase chain reaction. The prevalence of HBsAg, anti-HBc and anti-HBs was 0.1, 0.54 and 39.9% respectively. Out of 6 anti-HBc-positive individuals, 4 cases also had anti-HBs. One case revealed HBsAg co-existence and the other one showed isolated anti-HBc. HBV-DNA was not detected in HBsAg-negative specimens. A very low prevalence of HBsAg and isolated anti-HBc was observed and no occult HBV infection was detected. It seems that evasion mutants are not a potential threat for HBV universal immunization efficacy in the vaccinated population.

Item Type: Article
Keywords: Chronic hepatitis B; Expanded program of immunization; Infection; Occult HBV; Vaccination.
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
WC Communicable Diseases > WC 140-185 Sexually Transmitted Diseases
WC Communicable Diseases > WC 500-590 Virus Diseases
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Infectious Diseases
Page Range: pp. 218-223
Journal or Publication Title: Wiener medizinische Wochenschrift (1946)
Abstract and Indexing: ISI, Pubmed, Scopus
Volume: 170
Number: 9-10
Publisher: Springer
Identification Number: https://doi.org/10.1007/s10354-020-00748-z
ISSN: 1563-258X (Electronic)
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/6844

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