Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

In vivo and in vitro biocompatibility study of MnFe(2)O(4) and Cr(2)Fe(6)O(12) as photosensitizer for photodynamic therapy and drug delivery of anti-cancer drugs.

(2020) In vivo and in vitro biocompatibility study of MnFe(2)O(4) and Cr(2)Fe(6)O(12) as photosensitizer for photodynamic therapy and drug delivery of anti-cancer drugs. Drug development and industrial pharmacy. pp. 846-851. ISSN 1520-5762 (Electronic)

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Official URL: https://pubmed.ncbi.nlm.nih.gov/32301636/

Abstract

In The present project, a variety of MnFe(2)O(4) (Mn) and Cr(2)Fe(6)O(12) (Cr)-based nanocarriers (NCs) were synthesized as photosensitizer and NCs for delivery of chemotherapeutic curcumin (CUR) and provide a new structure for Photodynamic Therapy (PDT). For determining efficiency of NCs release study, MTT assay, lethal dose test and hemolysis assay were carried out. The release study showed the release of CUR from NCs was pH-dependent, but, every NCs had its own behavior for releasing the drug. The data acquired from the release study showed the CUR release from Mn can reach to over 90% at acidic media instead of 41% at neutral media. However, the CUR released from Cr were approximately equal as Cr had equal zeta potential at both media. Hemolysis activity and lethal dose test displayed the cytotoxicity of NCs was neglectable at both in vitro and in vivo study. Also, the results of anti-cancer activity assay (MTT assay) showed that both of Cr and Mn NCs are suitable systems for PDT. Therefore, the results demonstrated that Mn is suitable NCs for PDT and anticancer drugs delivery of therapeutic drugs.

Item Type: Article
Keywords: Photo dynamic therapy; anti-cancer drugs; biocompatibility; chromium; drug delivery; magnetite; manganese.
Subjects: QV Pharmacology > QV 243-269 Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacognosy and Pharmaceutical Biotechnology
Page Range: pp. 846-851
Journal or Publication Title: Drug development and industrial pharmacy
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 46
Number: 5
Publisher: Taylor & Francis
Identification Number: https://doi.org/10.1080/03639045.2020.1757698
ISSN: 1520-5762 (Electronic)
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/6842

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