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Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer

(2020) The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer. Canadian Journal of Physiology and Pharmacology. pp. 147-155. ISSN 0008-4212, 1205-7541

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Abstract

This study aimed to investigate the underlying mechanisms in anti-tumorigenesis effects of exercise through evaluation of inflammation and apoptosis. Twenty-four Wistar rats were divided into control, exercise, 1,2-dimethylhydrazine (DMH), and DMH + exercise. After a week, rats in the DMH group were given DMH twice a week for 2 weeks. Animals in the exercise groups performed exercise on a treadmill 5 days/week for 8 weeks. After 8 weeks of training, levels of COX-2, PCNA, Bax, Bcl-2, and procaspase-3/cleaved caspase-3 were assessed. Histological changes, number of aberrant crypt foci (ACF), and serum levels of TNF-alpha and IL-6 were also analyzed. ACF number was significantly decreased following the exercise program. Protein levels of COX-2 and PCNA and serum levels of IL-6 and TNF-alpha were significantly elevated in the rats receiving DMH and downregulated after performing the exercise program (P \textless 0.05). Exercise upregulated apoptosis, which was evident from the increased Bax/Bcl2 ratio, and enhanced the expression levels of activated caspase-3 as compared to the DMH group. The colonic architecture was improved in DMH + exercise. Exercise can effectively attenuate DMH-induced increase of inflammatory markers. Exercise induces apoptosis at the downstream of the inflammatory response. Therefore, exercise may play a role as a moderator of inflammation to exert protective effects against colon cancer.

Item Type: Article
Keywords: ACF,COX-2,PCNA,Pharmacology & Pharmacy,Physiology,apoptosis,cell-proliferation,colon,colorectal cancer,cyclooxygenase-2,dimethylhydrazine,exercise,expression,inhibition,mechanisms,pathways,physical-activity,prevention,risk
Subjects: QT Physiology > QT104-172 Human Physiology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Physiology
Page Range: pp. 147-155
Journal or Publication Title: Canadian Journal of Physiology and Pharmacology
Abstract and Indexing: ISI, Scopus, Other
Quartile : Q3
Volume: 98
Number: 3
Publisher: ProQuest
Identification Number: https://doi.org/10.1139/cjpp-2019-0329
ISSN: 0008-4212, 1205-7541
ISBN: 0008-4212
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/6807

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