Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Interleukin 35 and Hepatocyte Growth Factor; as a novel combined immune gene therapy for Multiple Sclerosis disease

(2017) Interleukin 35 and Hepatocyte Growth Factor; as a novel combined immune gene therapy for Multiple Sclerosis disease. Medical Hypotheses. pp. 102-105. ISSN 0306-9877

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Abstract

An autoimmune demyelination disease of the Central Nervous System, Multiple Sclerosis, is a chronic inflammation which mostly involves young adults. Suffering people face functional loss with a severe pain. Most current MS treatments are focused on the immune response suppression. Approved drugs suppress the inflammatory process, but factually, there is no definite cure for Multiple Sclerosis. Recently developed knowledge has demonstrated that gene and cell therapy as a hopeful approach in tissue regeneration. The authors propose a novel combined immune gene therapy for Multiple Sclerosis treatment using anti-inflammatory and re-myelination of Interleukine-35 and Hepatocyte Growth Factor properties, respectively. In this hypothesis Interleukine-35 and Hepatocyte Growth Factor introduce to Mesenchymal Stem Cells of EAE mouse model via an adenovirus based vector. It is expected that Interleukine-35 and Hepatocyte Growth Factor genes expressed from MSCs could effectively perform in immunotherapy of Multiple Sclerosis.

Item Type: Article
Keywords: Multiple Sclerosis Interleukine-35 Mesenchymal Stem Cells Hepatocyte Growth Factor CNS MESENCHYMAL STEM-CELLS SIGNALING PATHWAY T-CELLS CYTOKINE RECEPTOR HGF SUPPRESSES AUTOIMMUNE STRATEGIES MEDICINE Medicine, Research & Experimental
Page Range: pp. 102-105
Journal or Publication Title: Medical Hypotheses
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 109
Identification Number: https://doi.org/10.1016/j.mehy.2017.09.017 <Go to ISI>://WOS:000418221200024
ISSN: 0306-9877
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/68

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