Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Comparative efficacy of honey 12.5% and chlorhexidine 0.2% mouthwashes on the oropharyngeal bacterial colonization in mechanically-ventilated patients: a randomized controlled trial

(2020) Comparative efficacy of honey 12.5% and chlorhexidine 0.2% mouthwashes on the oropharyngeal bacterial colonization in mechanically-ventilated patients: a randomized controlled trial. Journal of Traditional Chinese Medicine. pp. 440-446. ISSN 0255-2922

Full text not available from this repository.

Abstract

OBJECTIVE: To compare the efficacy of honey mouthwash 12.5% and chlorhexidine solution 0.2% to reduce the rate of oropharyngeal bacterial colonization in mechanically-ventilated patients. METHODS: This study was a randomized, single blind, phase III controlled clinical trial. Sixty patients newly admitted to internal and trauma Intensive Care Units of the two educational hospitals of Sanandaj city affiliated with Kurdistan University of Medical Sciences were selected by convenience sampling and allocated to two groups of 30 patients using random blocks design. In each group, the mouthwash was applied twice a day for four consecutive days. Swab samples were taken from the mouth and throat of all patients three times a day (pre- intervention, two days, and four days after the intervention) and then the samples were transferred onto the blood agar and eosin methylene blue (EMB) culture plates and investigated for bacterial growth and colonization after 24-48 h. RESULTS: The findings showed that oropharyngeal colonization was not significantly different between the two groups, pre-intervention, two days, and four days after the intervention (P \textgreater 0.05). Rinsing with honey mouthwash 12.5% led to the inhibition of Staphylococcus aureus and Pseudomonas aeruginosa on the fourth day of the intervention in all samples. CONCLUSION: None of the studied solutions contributed to the reduction of oropharyngeal bacterial colonization. It seems that the growth inhibition of Staphylococcus aureus and Pseudomonas aeruginosa by the honey 12.5% mouthwash in mechanically-ventilated patients need further investigation. (C) 2020 JTCM. All rights reserved.

Item Type: Article
Keywords: Chlorhexidine,Honey,Integrative & Complementary Medicine,Intensive Care Unit,Mouthwashes,Oropharyngeal colonization,Randomized controlled,Ventilators,decontamination,double-blind,icu,mechanical,oral care,pneumonia,prevention,trial
Subjects: W General Medicine. Health Professions > W 100-275 Medical, Dental, and Pharmaceutical Service Plans
Page Range: pp. 440-446
Journal or Publication Title: Journal of Traditional Chinese Medicine
Abstract and Indexing: ISI, Scopus, Other
Quartile : Q4
Volume: 40
Number: 3
Publisher: Elsevier
ISSN: 0255-2922
ISBN: 0255-2922
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/6799

Actions (login required)

View Item View Item