Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia

(2017) Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia. Artificial cells, nanomedicine, and biotechnology. pp. 1379-1387. ISSN 2169-141X (Electronic) 2169-1401 (Linking)

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Abstract

The use of lipidic nanoparticles can overcome the limitations of skin penetration of hydrophilic charged materials. Oleic acid as an ion pairing agent was used to enhance the encapsulation of positively charged arginine into lipophilic nanostructured lipid carrier (NLC). Histological study on the male hamsters was performed to assess the efficiency of drug delivery on hair growth. The accumulation of NLCs in the hair follicles was verified and in vivo studies showed more new hair follicle growth by utilizing arginine-loaded NLCs than arginine aqueous solution. It was concluded that employing ion pairing agent could enhance drug encapsulation into NLCs structure.

Item Type: Article
Keywords: Alopecia/*drug therapy Animals Arginine/*chemistry/metabolism/*therapeutic use Cricetinae Drug Carriers/*chemistry Drug Liberation Hair Follicle/*metabolism Lipids/*chemistry Male Nanostructures/*chemistry Particle Size Arginine Nlc alopecia dermal drug delivery nanostructured lipid carriers
Page Range: pp. 1379-1387
Journal or Publication Title: Artificial cells, nanomedicine, and biotechnology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 45
Number: 7
Identification Number: https://doi.org/10.1080/21691401.2016.1241794
ISSN: 2169-141X (Electronic) 2169-1401 (Linking)
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/646

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