Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

بررسي تداخل اثر بي دردي حاصل از JWH133 و دوزهاي معمول و بسيار ناچيز سلكوكسيب در موش سوري

(1388) بررسي تداخل اثر بي دردي حاصل از JWH133 و دوزهاي معمول و بسيار ناچيز سلكوكسيب در موش سوري. مجله علمي دانشگاه علوم پزشكي و خدمات درماني استان زنجان.

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Official URL: https://www.sid.ir/fa/journal/ViewPaper.aspx?ID=97...

Title

INTERACTION BETWEEN JWH133-INDUCED ANTINOCICEPTION AND TWO EXTREME DOSES OF CELECOXIB

Abstract

Background and Objective: JWH133 is known to have cannabinoid-2 (CB2) receptor agonist properties. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is also known to have antinociceptive properties. Endocannabinoids produce analgesia possibly through cyclooxygenase (COX) pathway. The aim of the present work was: to study the effect of celecoxib on JWH133 induced antinociception and to compare the effects of two different dose ranges of celecoxib (mg/kg and nano g/kg) on the JWH133 antiniciceptive effect. Materials and Methods: We have studied the possible interaction of administration of mg/kg (50-200 mg/kg) and Ultra-Low Dose (ULD) (25 and 50 ng/kg) of celecoxib on the antinociceptive effect of intraperitoneal (i.p.) injection of JWH133 using formalin test in mice. Results: JWH133 (0.01, 0.1 and 1 mg/kg) induced antinociceptive effect just in phase I of the formalin test. Celecoxib (50-200 mg/kg) and its ULD (25 and 50 ng/kg) attenuated and potentiated, JWH133 induced antinociception, respectively. Conclusions: It is concluded that JWH-133 induced antinociception is modulated by celecoxib and mg/kg doses of celecoxib showed opposite effects compare to its ultra-low doses.

Item Type: Article
Keywords: JWH133, ANTINOCICEPTION, CELECOXIB, ULTRA-LOW DOSE (ULD), MICE
Journal or Publication Title: مجله علمي دانشگاه علوم پزشكي و خدمات درماني استان زنجان
Abstract and Indexing: ISC
Depositing User: خانم گیتی شاه محمدی
URI: http://repository.zums.ac.ir/id/eprint/6400

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