Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

: اثر تيمار در تاريكي بر آستانه ي تشنج كلونيك و فعاليت صرعي ناشي از پنتيلن تترازول در موش سفيد آزمايشگاهي

(1389) : اثر تيمار در تاريكي بر آستانه ي تشنج كلونيك و فعاليت صرعي ناشي از پنتيلن تترازول در موش سفيد آزمايشگاهي. Journal of Advances in Medical and Biomedical Research.

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Official URL: http://zums.ac.ir/journal/article-1-1082-fa.html

Title

Effects of Dark Rearing on Clonic Seizure Threshold and Pentyleneterazol Induced Epileptiform Activity in Mice

Abstract

Background and Objective: Epileptic seizures are generally considered as complex and abnormal hyperexcitable phenomena in the brain. Probable changing of excitability in visual cortex by dark rearing (DR) might lead to clonic seizure. In this study the possible effect of dark rearing on Pentylenetetrazol (PTZ) - induced generalized clonic seizure was studied. Materials and Methods: To assess the generalized clonic seizure (GCS) threshold and incidence and latency of GCS, 0.5% Pentylenetetrazol was administrated intravenously and 80 mg/kg subcutaneously to the control and dark reared animals. Results: Our results showed that generalized clonic seizure threshold in DR group was not changed but occurring of GCS in DR animals was significantly lower and its latency was higher than the control animals. The tonic – clonic seizure was not different between the two groups. Conclusion: In spite of increasing seizure susceptibility in visual cortex by light deprivation, a kind of protection was observed in dark reared animals. Further studies seem to be necessary to elucidate the role of other factors such as melatonin.

Item Type: Article
Keywords: Clonic seizure, Dark rearing, Pentylenetetrazol
Journal or Publication Title: Journal of Advances in Medical and Biomedical Research
Abstract and Indexing: ISC
Depositing User: خانم گیتی شاه محمدی
URI: http://repository.zums.ac.ir/id/eprint/6369

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