Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

: اثرات سفيكسيم بر بافت شناسي بيضه و هورمون‌هاي محور هيپوفيز- گناد در موش بالغ نژادBalb/C

(1390) : اثرات سفيكسيم بر بافت شناسي بيضه و هورمون‌هاي محور هيپوفيز- گناد در موش بالغ نژادBalb/C. مجله‌ی علمی پژوهشی دانشگاه علوم پزشکی زنجان.

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Official URL: http://zums.ac.ir/journal/browse.php?a_code=A-10-4...

Title

Effects of Cefixime on the Testis Structure and Pituitary- Gonadal Hormones in Adult Balb/C Mice

Abstract

Background and Objective: Cefixime is an antimicrobial agent which has a widespread ability against various pathogens, especially gram-negative organisms. Today, physicians apply cephalosporins especially cefixime in a wide scale. Regarding the side effects of some of these antibiotics on reproductive system, this study was conducted to determine the effect of cefixime on pituitary- gonadal hormones, gonadotrophins and testes morphology in adult male mice. Materials and Methods: Eighteen male mice (age: 12-16 weeks, weight: 35 5 gr) were divided into three groups control, sham and experimental (6 mice in each group). Experimental group received cefixime (0.5 gr/kg/day) as a solution in dimethyl solfoxide (DMSO) for 10 days the sham group received only drug solvent (DMSO) via IP injection and the control group remained intact. The animals were weighed and sacrificed. Level of hormones was measured by Radioi Immuno Assay (RIA) method. Then, tissues were fixed in Buin's fixative. Sections were cut into 5 µm thicknesses and stained with Hematoxylin and Eosin (H& E). Data were analyzed using T-test and SPSS software. Results: Count of spermatogenic, Sertoli and leydig cells and titer of FSH significantly decreased in the experimental group in comparison with the control and sham groups (P<0.01 and P<0.05). In the experimental group, DHEA hormone decreased significantly (P<0.05) in comparison with sham. No significant differences were seen in other factors between the groups. Conclusion: Regarding physiological role of Sertoli cells during spermatogenesis, reduction of FSH hormone may lead to negative effects on the sperm production and reproductive potential of male mice.

Item Type: Article
Keywords: Cefixime, Testosterone, Gonadotrophins, Testis, Mice
Journal or Publication Title: مجله‌ی علمی پژوهشی دانشگاه علوم پزشکی زنجان
Abstract and Indexing: ISC
Depositing User: خانم گیتی شاه محمدی
URI: http://repository.zums.ac.ir/id/eprint/6349

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