Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

: مقايسه نتايج سنجش سرمي LDL-C به روش آنزيماتيك با روش محاسباتي فريد والد، دلونگ و فريد والد تعديل شده

(1386) : مقايسه نتايج سنجش سرمي LDL-C به روش آنزيماتيك با روش محاسباتي فريد والد، دلونگ و فريد والد تعديل شده. مجله دانش و تندرستي.

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Official URL: https://www.sid.ir/Fa/Journal/ViewPaper.aspx?ID=86...

Title

A COMPARISON OF DIRECT MEASUREMENT OF LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL IN SERUM WITH STANDARD FRIEDEWALD, DE-LONG AND MODIFIED FRIEDEWALD EQUATION

Abstract

Abstract: Introduction: Reduction of low density lipoprotein cholesterol (LDL-C) in persons with coronary heart disease (CHD) is targeted. First step in treatment of lowering the LDL-C level is lifestyle modification including diet, weight reduction and exercise. At second step, the lipid lowering drug should be added. Although direct measurement of LDL-C from serum is most accurate, but it is not cost-effective, so laboratories usually use the Friedewald equation that suffers from several limitations such as hypertriglyceridemia and variability of lipoprotein composition. The authors compared and determined the correlation of LDL-C from enzymatic measurement with LDL-C from calculating. Methods and Materials: A total of 475 fasting serum samples (199 males and 276 females with mean age of 56.3 years) with TG less than 400 mg/ dl in Imam Hossein hospital (Shahroud) were analyzed. According to serum TG levels, samples divided in four groups (<100, 100-199, 200-299, 300-400). Authors calculated the LDL-C and then compared with direct measurement. Data analyzed with SPSS and table curve packages. Results: The comparison between direct and calculated methods showed that: 1) Concordance with the difference of 0±20 mg/dl is low. 2) Friedewald showed more accuracy compared with other calculated methods (51.2% versus 38.7% and 42.7%). 3) with the raising of TG, the accuracy declines and the overestimation increases. Correlation coefficient was 0.66. Conclusion: An overestimation of approximately 0±20 mg/dl was found in over 50% of samples comparison with direct LDL-C. Therefore; direct measurement of LDL-C in patients with CHD is recommented.

Item Type: Article
Keywords: LOW DENSITY LIPOPROTEIN, TRIGLYCERIDE, FRIEDEWALD, MODIFIED FRIEDEWA-LD, DE-LONG AND DIRECT MEASUREMENT
Journal or Publication Title: مجله دانش و تندرستي
Abstract and Indexing: ISC
Depositing User: خانم گیتی شاه محمدی
URI: http://repository.zums.ac.ir/id/eprint/6345

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