(2017) Down-regulation of microRNA-182 and microRNA-183 predicts progression of osteosarcoma. Archives of medical science : AMS. pp. 1352-1356. ISSN 1734-1922 (Print) 1734-1922 (Linking)
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Abstract
Introduction: The aim of this study was to investigate the expression levels of microRNA-182 and microRNA-183 and their association with clinicopathological features in patients with osteosarcoma. Material and methods: Total RNA was purified from samples and noncancerous bone tissues and then quantitative real-time polymerase chain reaction was applied to evaluate the expression levels of microRNAs, and their relationship with clinicopathological features and survival in osteosarcoma patients. Results: Our findings showed that expression of MiR-182 was clearly lower in osteosarcoma bone tissue (mean +/- SD: 2.84 +/-.07) compared with noncancerous bone tissues (6.23 +/-1.72, p = 0.004). On the other hand, lower expression of MiR-183 was seen in osteosarcoma bone tissue (1.43 +/-0.59) when compared with normal tissues (4.36 +/-2.47, p = 0.036). Decreased expression of MiR-182 was clearly correlated with advanced clinical stage (p = 0.001), metastasis or recurrence (p = 0.024), and large tumor size (p = 0.032). Decreased expression of MiR-183 was associated with advanced TNM stage (p = 0.004), and metastasis or recurrence (p = 0.002). A multivariate Cox proportional hazards model revealed that low expression of MiR-182 and MiR-183 (p = 0.02; p = 0.016), TNM stage (p = 0.04), and metastasis or recurrence (p = 0.03) were significantly associated with poor survival as independent prognostic factors. Conclusions: These findings suggest that MiR-182 and MiR-183 may be associated with progression and metastasis of osteosarcoma.
Item Type: | Article |
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Keywords: | expression marker oncology pathology tumor |
Page Range: | pp. 1352-1356 |
Journal or Publication Title: | Archives of medical science : AMS |
Abstract and Indexing: | ISI, Pubmed, Scopus |
Quartile : | Q2 |
Volume: | 13 |
Number: | 6 |
Identification Number: | https://doi.org/10.5114/aoms.2016.60091 |
ISSN: | 1734-1922 (Print) 1734-1922 (Linking) |
Depositing User: | خانم مریم زرقانی |
URI: | http://repository.zums.ac.ir/id/eprint/618 |
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