Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Down-regulation of microRNA-182 and microRNA-183 predicts progression of osteosarcoma

(2017) Down-regulation of microRNA-182 and microRNA-183 predicts progression of osteosarcoma. Archives of medical science : AMS. pp. 1352-1356. ISSN 1734-1922 (Print) 1734-1922 (Linking)

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Introduction: The aim of this study was to investigate the expression levels of microRNA-182 and microRNA-183 and their association with clinicopathological features in patients with osteosarcoma. Material and methods: Total RNA was purified from samples and noncancerous bone tissues and then quantitative real-time polymerase chain reaction was applied to evaluate the expression levels of microRNAs, and their relationship with clinicopathological features and survival in osteosarcoma patients. Results: Our findings showed that expression of MiR-182 was clearly lower in osteosarcoma bone tissue (mean +/- SD: 2.84 +/-.07) compared with noncancerous bone tissues (6.23 +/-1.72, p = 0.004). On the other hand, lower expression of MiR-183 was seen in osteosarcoma bone tissue (1.43 +/-0.59) when compared with normal tissues (4.36 +/-2.47, p = 0.036). Decreased expression of MiR-182 was clearly correlated with advanced clinical stage (p = 0.001), metastasis or recurrence (p = 0.024), and large tumor size (p = 0.032). Decreased expression of MiR-183 was associated with advanced TNM stage (p = 0.004), and metastasis or recurrence (p = 0.002). A multivariate Cox proportional hazards model revealed that low expression of MiR-182 and MiR-183 (p = 0.02; p = 0.016), TNM stage (p = 0.04), and metastasis or recurrence (p = 0.03) were significantly associated with poor survival as independent prognostic factors. Conclusions: These findings suggest that MiR-182 and MiR-183 may be associated with progression and metastasis of osteosarcoma.

Item Type: Article
Keywords: expression marker oncology pathology tumor
Page Range: pp. 1352-1356
Journal or Publication Title: Archives of medical science : AMS
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 13
Number: 6
Identification Number:
ISSN: 1734-1922 (Print) 1734-1922 (Linking)
Depositing User: خانم مریم زرقانی

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