Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Natural terpenoids as a promising source for modulation of GABAergic system and treatment of neurological diseases

(2016) Natural terpenoids as a promising source for modulation of GABAergic system and treatment of neurological diseases. Pharmacological Reports. pp. 671-679. ISSN 1734-1140

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Abstract

gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter reducing neural excitability in the mammalian central nervous system (CNS) with three subclasses of receptors. Several conventional drugs and compounds modulate the GABAergic system, demonstrating different pharmacological effects. In this review, interactions of natural terpenoids with the GABAergic system are highlighted with relation to disorders like anxiety, insomnia, convulsion, pain, and cognitive deficits. Terpenoids with various structures affect the function of the GABAergic system via dissimilar mechanisms. Most of the discussed compounds interact with GABA receptors, but especially with the GABA(A) subtype. This may be due to the fact that researchers tend to assess the interaction of compounds using GABA(A) receptors. However, bilobalide, a sesquiterpene, showed anticonvulsant properties through the activation of glutamic acid decarboxylase (GAD) enzyme, which is a key enzyme in biosynthesis of GABA. Therefore, further studies evaluating and comparing terpenoids of different classes and their interaction with the GABA system, along with their pharmacokinetic properties, could be worthwhile in future studies. (C) 2016 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.

Item Type: Article
Keywords: Terpenoids GABA Convulsion Anxiety GABA(A) RECEPTOR MODULATORS VALERENIC ACID GINKGO-BILOBA ALZHEIMERS-DISEASE MAJOR CONSTITUENT CORTICAL-NEURONS INDUCED SEIZURES ESSENTIAL OILS ALPHA-THUJONE DOWN-SYNDROME Pharmacology & Pharmacy
Page Range: pp. 671-679
Journal or Publication Title: Pharmacological Reports
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 68
Number: 4
Identification Number: https://doi.org/10.1016/j.pharep.2016.03.014
ISSN: 1734-1140
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/601

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