Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

پروکلسی‌تونین سرمی یک عامل پیش‌بینی‌‌کننده پاسخ به درمان در بیماران مبتلا به سپسیس باکتریال بستری در ICU

(1389) پروکلسی‌تونین سرمی یک عامل پیش‌بینی‌‌کننده پاسخ به درمان در بیماران مبتلا به سپسیس باکتریال بستری در ICU. مجله دانشکده پزشکی، دانشگاه علوم پزشکی تهران.

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Official URL: http://tumj.tums.ac.ir/article-1-372-fa.html

Title

Plasma procalcitonin level as a predictor of treatment response in ICU patients with bacterial sepsis

Abstract

Background: Sepsis is one of the most important causes of mortality in severely ill ICU patients. At least, a part of high mortality rate in sepsis patients is due to less specific clinical symptoms for prompt diagnosis. Recently some studies report that serum levels of procalcitonin will increase in these patients but changes of serum levels following treatments is not known. This study was designed to determin procalcitonin levels in patients with bacterial infectious disease in ICU, initially and during therapy and compare the levels during response to treatment. Methods: This prospective cross-sectional study was conducted on ICU patients with infectious diseases, blood specimen collected on day 1 and then in days 3 and 7 of ICU admission. The semi-quantitative PCT-Q test was performed. Results: Thirty five patients, 22(62.9 %) men and 13(37.1%) women, were enrolled in this study. 18(51.4%) patients died. Procalcitonin level in most patients in admission day was more than 10 ng/ml [16 (45.7%)] but in patients that react to treatment, decline to lower than 0.5 ng/ml [14(77.8%)]. Mean rank of procalcitonin level from 1.14 ng/ml in first day reached to 2.72 ng/ml in seventh day (p<0.0001). Conclusions: This study showed that serum procalcitonin levels in ICU patients with bacterial sepsis significantly decrease following response to treatment. The measurement of serum procalcitonin in ICU patients with bacterial infectious diseases at first arrival day and following treatment is recommended.

Item Type: Article
Keywords: Sepsis, procalcitonin, prognosis
Journal or Publication Title: مجله دانشکده پزشکی، دانشگاه علوم پزشکی تهران
Abstract and Indexing: ISC
Depositing User: خانم گیتی شاه محمدی
URI: http://repository.zums.ac.ir/id/eprint/5991

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