Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

ANTI-INFLAMMATORY EVALUATION OF LIPOSOMAL PREDNISOLONE IN WISTAR RATS

(2016) ANTI-INFLAMMATORY EVALUATION OF LIPOSOMAL PREDNISOLONE IN WISTAR RATS. Acta Medica Mediterranea. pp. 867-872. ISSN 0393-6384

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Abstract

The aim of the present study was to evaluate the anti-inflammatory ability of liposomal prednisolone in a carrageenan induced acute inflammatory paw edema model. Drug delivery to inflammatory tissue via liposomal nanoparticles may improve therapeutic agents' risk-benefit ratios. prednisolone encapsulated in long-circulating liposomes can inhibit inflammation after administration. The mechanism by which liposomal prednisolone inhibits Production of inflammatory factor. Variable efficacies have been reported for prednisolone drugs as anti-inflammatory treatment. Liposomal prednisolone was administered to male Wistar rats. carrageenan at a concentration of 1 was injected into hind paw of rats. The thickness of paws was measured by caliper within 0, 1, 2, 3, and 4 hours after the injections to confirm the inflammation. Blood samples were collected immediately after carrageenan injection and also 12 h thereafter. The sera were separated for measurements of interleukin 6 (IL-6). The prednisolone and liposomal prednisolone are efficacious in controlling the paw sizes, as indicators of inflammation; the liposomal prednisolone is remarkably more effective in controlling the inflammation in long term. Both the drug forms were clearly efficient in lowering the IL-6 level. Mostly noteworthy, the liposomal prednisolone was remarkably more efficient in lowering IL-6 levels.

Item Type: Article
Keywords: liposomal long circulation Inflammation Interleukin 6 GLUCOCORTICOIDS ARTHRITIS DELIVERY DISEASES SYSTEMS Medicine, General & Internal
Page Range: pp. 867-872
Journal or Publication Title: Acta Medica Mediterranea
Abstract and Indexing: ISI, Scopus
Quartile : Q4
Volume: 32
ISSN: 0393-6384
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/589

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