Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Effect of Molybdenum Trioxide Nanoparticles on Ovary Function in Female Rats

(2019) Effect of Molybdenum Trioxide Nanoparticles on Ovary Function in Female Rats. J Adv Med Biomed Res. 2019; 27(121): 48-53. pp. 48-53. ISSN 2676-6264

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Official URL: http://zums.ac.ir/journal/article-1-5388-en.pdf

Abstract

Background & Objective: Molybdenum trioxide nanoparticles (MoO3 NPs) have widespread applications in industries. However, the toxic and non-toxic effects of MoO3 NPs have not been fully investigated yet. In this study, effects of MoO3 NPs on ovary function of female rats were studied. Materials & Methods: In this study, 21 female rats were randomly divided into three groups (n=7): the first group did not receive any treatment, the second one received normal saline, and the third group received 5 mg/kg MoO3 NPs in normal saline via intraperitoneal injection during a period of 28 days. Serum concentrations of estrogen, progesterone, luteinizing hormone, and follicle stimulating hormone were measured. Also, changes of ovaries, uterine weights, uterine, and length of uterine horns were studied. Results: The serum level of estrogen in the MoO3 NPs exposed group was significantly attenuated; those of luteinizing hormones and follicle stimulating hormone were elevated while progesterone level change was insignificant. The weights of the right ovary and the uterine body decreased significantly in the exposed group. Conclusion: Our data showed that MoO3 nanoparticle exposure could cause an imbalance of sex hormones and decrease in body and ovarian weights in thefemale rats.

Item Type: Article
Keywords: Female rats, Reproduction,Nanoparticles
Subjects: WQ Obstetrics > WQ 215-270 Pregnancy Complications
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Clinical Biochemistry
Page Range: pp. 48-53
Journal or Publication Title: J Adv Med Biomed Res. 2019; 27(121): 48-53
Abstract and Indexing: Scopus
Volume: 27
Number: 121
Publisher: Zanjan University of Medical Sciences
Identification Number: https://doi.org/10.30699/jambs.27.121.48
ISSN: 2676-6264
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5788

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