Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Overview development and applications of CRISPR-Cas systems after a decade of research with a glance at anti-CRISPR proteins

(2019) Overview development and applications of CRISPR-Cas systems after a decade of research with a glance at anti-CRISPR proteins. Reviews in Medical Microbiology. pp. 47-55. ISSN 0954-139X

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Abstract

CRISPR and its associated proteins that are called, the CRISPR-Cas systems, confers adaptive immunity against exogenic elements in many bacteria and also most archaea. Unlike the restriction modification system that provides a defense against any foreign DNA lacking a protective methyl-tag in the target site, the CRISPR-Cas systems are invader-specific, adaptive, and heritable. This immunity is gained by integrating short fragments of foreign DNA into CRISPRloci. CRISPR-derived transcripts assemble with Cas proteins to target similar foreign nucleic acids for degradation. Moreover, in recent years investigation of anti-CRISPR proteins has provided important new insight into CRISPR-Cas systems. Here we review an update on the development and the applications of CRISPR-Cas systems and discuss the potential of these phage-resistance machineries. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Article
Keywords: anti-CRISPR proteins,genome editing
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Microbiology
Page Range: pp. 47-55
Journal or Publication Title: Reviews in Medical Microbiology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q4
Volume: 30
Number: 1
Publisher: ovid
Identification Number: https://doi.org/10.1097/mrm.0000000000000153
ISSN: 0954-139X
ISBN: 0954-139X
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5770

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