Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

An evaluation of the effect of pulsed wave low-level laser therapy on the biomechanical properties of the vertebral body in two experimental osteoporosis rat models

(2016) An evaluation of the effect of pulsed wave low-level laser therapy on the biomechanical properties of the vertebral body in two experimental osteoporosis rat models. Lasers in Medical Science. pp. 305-314. ISSN 0268-8921

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Abstract

Osteoporosis (OP) increases vertebral fragility as a result of the biomechanical effects of diminished bone structure and composition. This study has aimed to assess the effects of pulsed wave low-level laser therapy (PW LLLT) on cancellous bone strength of an ovariectomized (OVX-d) experimental rat model and a glucocorticoid-induced OP (GIOP) experimental rat model. There were four OVX-d groups and four dexamethasone-treated groups. A group of healthy rats was used for baseline evaluations. The OVX-d rats were further subdivided into the following groups: control rats with OP, OVX-d rats that received alendronate, OVX-d rats treated with PW LLLT, and OVX-d rats treated with alendronate and PW LLLT. The remaining rats received dexamethasone and were divided into four groups: control, alendronate-treated rats, laser-treated rats, and laser-treated rats with concomitant administration of alendronate. PW LLLT (890 nm, 80 Hz, 0.972 J/cm(2)) was performed on the spinal processes of the T12, L1, L2, and L3 vertebras. We extracted the L1 vertebrae and submitted them to a mechanical compression test. Biomechanical test findings showed positive effects of the PW LLLT and alendronate administration on increasing bending stiffness and maximum force of the osteoporotic bones compared to the healthy group. However, laser treatment of OVA-d rats significantly increased stress high load compared to OVA-d control rats. PW LLLT preserved the cancellous (trabecular) bone of vertebra against the detrimental effects of OV-induced OP on bone strength in rats compared to control OV rats.

Item Type: Article
Keywords: Low-level laser therapy Glucocorticoid administration Osteoporosis Ovariectomy Alendronate Biomechanical properties Rat Lumbarvertebra Cancellous bone BONE NODULE FORMATION LOW-POWER LASER CALVARIAL CELLS NEEDLE SYSTEM 830-NM LASER IRRADIATION EPIDEMIOLOGY COMBINATION DEFICIENCY EXPRESSION Engineering, Biomedical Surgery
Page Range: pp. 305-314
Journal or Publication Title: Lasers in Medical Science
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 31
Number: 2
Identification Number: https://doi.org/10.1007/s10103-015-1842-2
ISSN: 0268-8921
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/576

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