Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Frequency and subtype of BK virus infection in Iranian patients infected with HIV

(2016) Frequency and subtype of BK virus infection in Iranian patients infected with HIV. Medical Microbiology and Immunology. pp. 57-62. ISSN 0300-8584

Full text not available from this repository. (Request a copy)

Official URL: http://apps.webofknowledge.com/full_record.do?prod...

Abstract

Human polyomavirus BK virus (BKV) is a double-stranded DNA virus that infects approximately 90 of the general population as a subclinical or mild infection. In immunosuppressed patients, such as HIV cases, BKV may be reactivated resulting hemorrhagic cystitis and tubulointerstitial nephritis. However, there are limited studies on prevalence and molecular epidemiology of BKV in Iran. We therefore aimed to evaluate the prevalence and sub-types of BKV in Iranian HIV patients. A total of 99 patients with HIV infection were enrolled in the study. Presence of BKV DNA in plasma was evaluated by nested PCR. PCR products were sequenced directly, and phylogenetic analysis was performed. BKV DNA was detected in 8.08 of HIV patients. BKV viremia presented in 4 out of 25 patients (16 ) not receiving antiretroviral therapy in comparison with 4 out 74 of HAART-treated patients (5.4 ) (P = 0.023). In patients with CD4 counts >= 200 cells/mm(3), viremia was found more commonly (7/80 = 8.8 ) than in those with lower counts (1/19 = 5.2 ) (not significant). All sequenced BKV isolates belonged to subtype Ib-2. Our findings indicated that the prevalence of BKV viremia is relatively prevalent in patients with HIV infection and significantly higher in naIve than HAART-treated cases. Therefore, HAART can eliminate BKV infection from plasma and reduce viremia although the actual implication of BKV viremia in HIV patients is not clear.

Item Type: Article
Keywords: Human immunodeficiency virus (HIV) BK virus (BKV) Prevalence Subtype RENAL-TRANSPLANT RECIPIENTS HEMORRHAGIC CYSTITIS POLYOMAVIRUS-BK JC VIRUSES PREVALENCE EXCRETION AIDS NEPHROPATHY POPULATIONS VIREMIA Immunology Microbiology
Page Range: pp. 57-62
Journal or Publication Title: Medical Microbiology and Immunology
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q2
Volume: 205
Number: 1
Identification Number: https://doi.org/10.1007/s00430-015-0426-x
ISSN: 0300-8584
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/573

Actions (login required)

View Item View Item