Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

New Insight about Biocompatibility and Biodegradability of Iron Oxide Magnetic Nanoparticles: Stereological and In Vivo MRI Monitor

(2019) New Insight about Biocompatibility and Biodegradability of Iron Oxide Magnetic Nanoparticles: Stereological and In Vivo MRI Monitor. Scientific Reports. pp. 10-1. ISSN 2045-2322

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Official URL: https://www.nature.com/articles/s41598-019-43650-4...

Abstract

Iron oxide magnetic nanoparticles (IONPs) have attracted enormous attention because of their extensive medicinal and industrial applicability. PEGylated L-arginine modified iron oxide magnetic nanoparticles (PEG-Arg (R) IONPs) were synthesized and functioned in the present research as MRI contrast agents considered in vivo BALB/c model. The Synthesized PEG-Arg (R) IONPs were tracked in certain time intervals by MRI. The intensity of MR imaging of kidneys increased after administration of PEG-Arg (R) IONPs, which could confirm the emission of these nanoparticles by kidneys shortly after administration. Although PEG-Arg (R) IONPs were uptake by liver within 2 hours after injection, whereas, the signal change intensity of spleen, heart and kidneys confirmed that PEG-Arg (R) IONPs existed in other organs. The results illustrated that IONPs coated with PEGylated natural amino acid thin layers had a long circulation time and could be served asT(2) contrast agents for diagnosis purpose. Notably, to the best of our knowledge, it was the first time the biocompatibility and biodegradability of IONPs was studied and evaluated by stereological and MRI technique.

Item Type: Article
Keywords: Oxide Magnetic ,Biocompatibility ,Biodegradability
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacognosy and Pharmaceutical Biotechnology
Page Range: pp. 10-1
Journal or Publication Title: Scientific Reports
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 9
Publisher: Nature, proQuest
Identification Number: https://doi.org/10.1038/s41598-019-43650-4
ISSN: 2045-2322
ISBN: 2045-2322
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5691

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