Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Trabecular meshwork mesenchymal stem cell transplantation improve motor symptoms of parkinsonian rat model

(2019) Trabecular meshwork mesenchymal stem cell transplantation improve motor symptoms of parkinsonian rat model. Biologicals. pp. 61-67. ISSN 1045-1056

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Stem cell transplantation is a new therapeutic strategy in the treatment of neurodegenerative disorders such as Parkinson's disease (PD). Therefore, in this study, the therapeutic effects of Trabecular Meshwork Mesenchymal Stem Cells (TM-MSCs) transplantation, as a new source of mesenchymal stem cells, were evaluated in the animal model of PD. After the development and confirmation of hemi-parkinsonian rats by administration of 6-hydroxy dopamine (6-OHDA) and apomorphine-induced rotation test, green fluorescent protein (GFP) labeled TM-MSCs (normal and induced cells) were transplanted in the striatum of rats. Next, the rotation test, rotarod test, open field, passive avoidance memory tests and immunohistochemistry for tyrosine hydroxylase (TH) were done. The results showed that the number of turns significantly decreased and the improvement of motor performance was achieved after cell transplantation. However, there was no significant difference in passive avoidance memory of animals documented by shuttle box test. The number of GFP- labeled cells expressing TH significantly is increased compared to the vehicle group. Collectively, it seems that TM-MSCs and induced TM-MSCs cell transplantation have positive effects on some aspects of the animal model of PD. Other studies may reveal the potentially positive aspects of these cells in the laboratory and clinical studies.

Item Type: Article
Keywords: *Mesenchymal Stem Cell Transplantation,*Mesenchymal Stem Cells/metabolism/pathology,*Motor Activity,*Parkinson Disease, Secondary/metabolism/pathology/therapy,*Trabecular Meshwork/metabolism/pathology,Allografts,Animals,Disease Models, Animal,Male,Parkinson's disease,Rats,Rats, Wistar,Stem cell transplantation,Trabecular meshwork mesenchymal stem cells,Tyrosine hydroxylase
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Physiology
Page Range: pp. 61-67
Journal or Publication Title: Biologicals
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 61
Publisher: Elsevier
Identification Number:
ISSN: 1045-1056
ISBN: 1045-1056
Depositing User: خانم فائزه مظفری

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