Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

Intraspinal delivery of bone marrow stromal cell-derived neural stem cells in patients with amyotrophic lateral sclerosis: A safety and feasibility study

(2016) Intraspinal delivery of bone marrow stromal cell-derived neural stem cells in patients with amyotrophic lateral sclerosis: A safety and feasibility study. Journal of the Neurological Sciences. pp. 174-181. ISSN 0022-510X

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Abstract

Background: Stem cells have been used in several studies with different methodologies to treat patients with ALS. Methods: In this safety and feasibility study, 11 patients with definite or probable ALS according to El Escorial criteria were selected. 3 patients were excluded due to inadequate bone marrow or safety measures after acquisition of bone marrow. Bone marrow stromal cell-derived neural stem cells were injected in C7-T1 spinal cord under general anesthesia. Patients were followed for 12 months after injection with manual muscle testing, ALSFRS-R, quality of life changes, pulmonary function test and electromyography. Results: None of the patients had perioperative mortality or major morbidity. One patient had temporary deterioration in lower extremities after injection which improved after a few weeks. In the 12 months post-injection, only one patient died due to pulmonary embolism. From the remaining 7 patients, all had a stable course after 4 months and 5 were stable for the first 8 months post-injection and deteriorated afterwards. Discussion: In this study, intraspinal injection of bone marrow derived neural stem cells appears to be safe. Patients experienced a temporary stabilization for the first few months post-injection and then gradually deteriorated. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Amyotrophic lateral sclerosis Neural stem cells Intraspinal injection Cervical cord METHODOLOGICAL APPROACH FOLLOW-UP TRANSPLANTATION TRIAL RILUZOLE INDUCTION THERAPY Clinical Neurology Neurosciences
Page Range: pp. 174-181
Journal or Publication Title: Journal of the Neurological Sciences
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 362
Identification Number: https://doi.org/10.1016/j.jns.2016.01.051
ISSN: 0022-510X
Depositing User: خانم مریم زرقانی
URI: http://repository.zums.ac.ir/id/eprint/557

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