Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

(2019) The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis. BMC Cancer. p. 527. ISSN 1471-2407

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Official URL: https://pubmed.ncbi.nlm.nih.gov/31151429/

Abstract

BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence. METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis. RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21-2.01), and it was 1.85 (95% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34-1.97). CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

Item Type: Article
Keywords: Diabetes,Diabetes Complications/*epidemiology,Endometrial Cancer,Endometrial Neoplasms/complications/*epidemiology,Female,Humans,Incidence,Meta-analysis,Risk
Subjects: QZ Pathology > QZ 200-380 Neoplasms
WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 200-226 Metabolic Diseases
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Obstetrics and Gynecology
Page Range: p. 527
Journal or Publication Title: BMC Cancer
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q3
Volume: 19
Number: 1
Publisher: ProQuest
Identification Number: https://doi.org/10.1186/s12885-019-5748-4
ISSN: 1471-2407
ISBN: 1471-2407
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5541

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