Repository of Research and Investigative Information

Repository of Research and Investigative Information

دانشگاه علوم پزشکی و خدمات بهداشتی درمانی زنجان

MicroRNAs association with azoospermia, oligospermia, asthenozoospermia, and teratozoospermia: a systematic review

(2020) MicroRNAs association with azoospermia, oligospermia, asthenozoospermia, and teratozoospermia: a systematic review. J Assist Reprod Genet. pp. 763-775. ISSN 1058-0468

Full text not available from this repository.

Official URL: https://pubmed.ncbi.nlm.nih.gov/32189180/

Abstract

Infertility is a major health problem across the world. One of the main reasons for male infertility are defects in sperm. Semen analysis is the most common test utilized to evaluate male fertility and since it suffers from multiple drawbacks, reproduction scientists have tried to find new molecular markers for detecting sperm defects. MicroRNAs (miRNAs) are small molecules in cells which take part in regulating gene expression. Various studies have confirmed miRNAs to have a role in defining multiple sperm characteristics, including sperm count, motility, and morphology. In this paper, we have systematically reviewed the role of miRNAs in infertile men with sperm defects including azoospermia, oligospermia, asthenozoospermia, and teratozoospermia. Also, we have assembled various bioinformatics tools to come up with a pipeline for predicting novel miRNAs which could possibly participate in sperm count, motility, and morphology. Also, related KEGG and GO terms for predicted miRNAs have been included in order to highlight their role in sperm function. Our study emphasizes the potential role of miRNAs in male infertility and provides a general overview for future studies aiming to find robust molecular markers for this condition.

Item Type: Article
Keywords: Asthenozoospermia,Azoospermia,Bioinformatics,MicroRNA,Oligospermia,Teratozoospermia
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics
Page Range: pp. 763-775
Journal or Publication Title: J Assist Reprod Genet
Abstract and Indexing: ISI, Pubmed, Scopus
Quartile : Q1
Volume: 37
Number: 4
Publisher: Springer , proQuest
Identification Number: https://doi.org/10.1007/s10815-019-01674-9
ISSN: 1058-0468
ISBN: 1058-0468
Depositing User: خانم فائزه مظفری
URI: http://repository.zums.ac.ir/id/eprint/5540

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